<?xml version="1.0" encoding="UTF-8"?><own:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:own="http://www.sec.gov/edgar/ownership">
  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144</own:submissionType>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0001759241</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



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  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0001815442</own:issuerCik>
      <own:issuerName>KYMERA THERAPEUTICS, INC.</own:issuerName>
      <own:secFileNumber>001-39460</own:secFileNumber>
      <own:issuerAddress>
        <com:street1>500 North Beacon Street</com:street1>
        <com:street2>4th Floor</com:street2>
        <com:city>Watertown</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02472</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>8572855300</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Atlas Venture Opportunity Fund I, LP</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>Shareholder</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>Merrill Lynch</own:name>
        <own:address>
          <com:street1>555 California Street</com:street1>
          <com:street2>18th Floor</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94104</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>385</own:noOfUnitsSold>
      <own:aggregateMarketValue>34599.95</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>81642394</own:noOfUnitsOutstanding>
      <own:approxSaleDate>04/15/2026</own:approxSaleDate>
      <own:securitiesExchangeName>Nasdaq</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>03/11/2020</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Private Placement</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>385</own:amountOfSecuritiesAcquired>
      <own:paymentDate>03/11/2020</own:paymentDate>
      <own:natureOfPayment>Cash</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>Atlas Venture Fund X, L.P.</own:name>
        <own:address>
          <com:street1>300 Technology Sq Ste 8</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:saleDate>03/02/2026</own:saleDate>
      <own:amountOfSecuritiesSold>71814</own:amountOfSecuritiesSold>
      <own:grossProceeds>6472674.74</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>Atlas Venture Opportunity Fund I, L.P.</own:name>
        <own:address>
          <com:street1>300 Technology Sq Ste 8</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:saleDate>03/02/2026</own:saleDate>
      <own:amountOfSecuritiesSold>10052</own:amountOfSecuritiesSold>
      <own:grossProceeds>905997.81</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>Bruce Booth</own:name>
        <own:address>
          <com:street1>300 Technology Sq Ste 8</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:saleDate>04/14/2026</own:saleDate>
      <own:amountOfSecuritiesSold>4159</own:amountOfSecuritiesSold>
      <own:grossProceeds>374199.56</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:noticeSignature>
      <own:noticeDate>04/15/2026</own:noticeDate>
      <own:planAdoptionDates>
        <own:planAdoptionDate>12/11/2025</own:planAdoptionDate>
      </own:planAdoptionDates>
      <own:signature>Ommer Chohan</own:signature>
    </own:noticeSignature>
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