Segment Reporting - Schedule of Segment Reporting Presents Reportable Segment Profit and Loss (Details) - USD ($) $ in Thousands		12 Months Ended
		Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Segment Reporting Information [Line Items]
Revenue		$ 39,211	$ 47,072	$ 78,592
Less:
Research and Development Expense, Total		316,568	240,248	189,081
Other external research and development expense	[1]	92,165	84,981	94,700
Research and development compensation and related personnel expense	[2]	90,346	75,975	65,039
Research and development overhead and administrative costs		47,442	39,487	29,342
General and administrative	[3]	68,187	63,534	55,041
Interest and other expense	[4]	4,225	5,174	196
Plus:
Interest income		38,418	38,026	18,764
Segment net loss		(311,351)	(223,858)	(146,962)
STAT6 Programs [Member]
Less:
Research and Development Expense, Total		$ 86,615	$ 39,805	$ 0

[1] (1) Certain prior period amounts have been recast to conform with current period presentation.

[2] (2) Research and development compensation and related personnel expense for the years ended December 31, 2025, 2024 and 2023 is inclusive of $31.5 million, $27.8 million, and $21.6 million of stock-based compensation expense, respectively.

[3] (3) General and administrative expense for the years ended December 31, 2025, 2024 and 2023 is inclusive of $28.4 million, $27.2 million, and $21.6 million of stock-based compensation expense, respectively.

[4] (4) Other expense for the years ended December 31, 2025 and 2024 is inclusive of a $3.9 million and $4.9 million impairment of long-lived assets, respectively.