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Extended research term of collaboration.

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Preferred stock issuance premium.

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Remaining research term of collaboration.

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Upfront payment.

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Collaborations - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands			3 Months Ended			12 Months Ended
	Jul. 07, 2020	May 09, 2019	Mar. 31, 2025	Mar. 31, 2024	Sep. 30, 2023	Dec. 31, 2024	Dec. 31, 2023
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Cost reimbursement payment received			$ 900
Unbilled accounts receivable			20,000
Research and development			$ 80,255	$ 48,819
Remaining research term of collaboration			6 months
Revenue			$ 22,100	10,287
Deferred Revenue			3,700
Milestone Two [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenue recognized recorded in deferred revenue			19,800
Unconstrained Consideration			20,000				$ 55,000
Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenue Recognized			75,000
Minimum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenue Recognized			71,300
Sanofi Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront payment	$ 150,000
Collaboration agreement transaction price	150,000
Revenue recognized recorded in deferred revenue			22,100	10,300
Unsatisfied performance obligation			11,500			$ 13,600
Revenue						3,100
Unconstrained Consideration			20,000
Sanofi Agreement \| Milestone One [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration revenue recognised					$ 40,000
Sanofi Agreement \| Milestone Two [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration revenue recognised					$ 15,000
Sanofi Agreement \| Collaboration Target 1
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration agreement transaction price	120,000
Sanofi Agreement \| Collaboration Target 2
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration agreement transaction price	30,000
Sanofi Agreement \| Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development milestone payments	1,480,000
Commercial Milestone Payments	700,000
Sanofi Agreement \| Minimum \| IRAK4 Program
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development milestone payments	1,000,000
Commercial Milestone Payments	$ 400,000
Vertex Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Unsatisfied performance obligation			$ 0	$ 0		$ 0
Initial research term of collaboration		4 years
Extended research term of collaboration		1 year
Vertex Agreement \| Series B-1 Preferred Stock
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration agreement transaction price		$ 55,900
Non refundable upfront payment received		$ 50,000
Stock Issued During Period, Shares, New Issues		3,059,695
Stock issued price per share		$ 6.54
Preferred stock premium		$ 5,900
Vertex Agreement \| Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Eligible to receive payments including development, regulatory and commercial milestones		$ 170,000