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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Collaboration revenue $ 47,072 $ 78,592 $ 46,826
Revenue from Contract with Customer, Product and Service [Extensible List] Collaboration Revenues From Related Party [Member] Collaboration Revenues From Related Party [Member] Collaboration Revenues From Related Party [Member]
Operating expenses:      
Research and development $ 240,248 $ 189,081 $ 164,248
General and administrative [1] 63,534 55,041 43,834
Impairment of long-lived assets 4,925 0 0
Total operating expenses 308,707 244,122 208,082
Loss from operations (261,635) (165,530) (161,256)
Other income (expense):      
Interest and other income 38,026 18,764 6,624
Interest and other expense (249) (196) (176)
Total other income 37,777 18,568 6,448
Net loss (223,858) (146,962) (154,808)
Other comprehensive loss:      
Unrealized (loss) gain on marketable securities (933) 4,397 (4,289)
Total comprehensive loss (224,791) (142,565) (159,097)
Reconciliation of net loss to net loss attributable to common stockholders:      
Net Income (Loss) (223,858) (146,962) (154,808)
Net loss attributable to common stockholders $ (223,858) $ (146,962) $ (154,808)
Net loss per share, basic $ (2.98) $ (2.52) $ (2.87)
Net loss per share, diluted $ (2.98) $ (2.52) $ (2.87)
Weighted average common shares outstanding, diluted 75,043,991 58,365,499 53,933,229
Weighted average common shares outstanding, basic 75,043,991 58,365,499 53,933,229
[1] General and administrative expense for the years ended December 31, 2024, 2023 and 2022 is inclusive of $27.2 million, $21.6 million, and $17.5 million of stock-based compensation expense, respectively.