Segment Reporting (Tables)

12 Months Ended

Dec. 31, 2024

Segment Reporting [Abstract]

Schedule of Segment Reporting Presents Reportable Segment Profit and Loss

The following table presents reportable segment profit and loss, including significant expense categories, attributable to the Company’s reportable segment for the periods presented:

	Year ended December 31,
	2024			2023			2022
Revenue	$	47,072		$	78,592		$	46,826
Less:
Research and development expenses
External research and development:
STAT6		39,805			—			—
TYK2		18,292			—			—
IRAK4		7,065			13,762			17,850
MDM2		8,516			8,170			11,823
STAT3		7,199			11,490			8,332
Other external research and development expense		43,909			61,278			51,388
Research and development compensation and related personnel expense (1)		75,975			65,039			55,751
Research and development overhead and administrative costs		39,487			29,342			19,104
General & administrative (2)		63,534			55,041			43,834
Interest and other expense (3)		5,174			196			176
Plus:
Interest income		38,026			18,764			6,624
Segment net loss	$	(223,858	)	$	(146,962	)	$	(154,808	)

(1) Research and development compensation and related personnel expense for the years ended December 31, 2024, 2023 and 2022 is inclusive of $27.8 million, $21.6 million, and $18.0 million of stock-based compensation expense, respectively.

(2) General and administrative expense for the years ended December 31, 2024, 2023 and 2022 is inclusive of $27.2 million, $21.6 million, and $17.5 million of stock-based compensation expense, respectively.

(3) Other expense for the year ended December 31, 2024 is inclusive of a $4.9 million impairment of long-lived assets.