Collaborations - Change in Accounts Receivable, Contract Asset and Liabilities (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2022 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Accounts receivable and contract assets, Beginning balance	$ 135
Accounts receivable and contract assets, Additions	15,702
Accounts receivable and contract assets, Deductions	(13,300)
Accounts receivable and contract assets, Ending balance	2,537
Contract Liabilities, Beginning balance	101,034
Contract Liabilities, Additions	9,052
Contract Liabilities, Deductions	(46,826)
Contract Liabilities, Ending balance	63,260
Billed Receivables - Sanofi
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Accounts receivable and contract assets, Beginning balance	0
Accounts receivable and contract assets, Additions	6,650
Accounts receivable and contract assets, Deductions	(6,650)
Accounts receivable and contract assets, Ending balance	0
Unbilled Receivables - Sanofi
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Accounts receivable and contract assets, Beginning balance	135
Accounts receivable and contract assets, Additions	9,052
Accounts receivable and contract assets, Deductions	(6,650)
Accounts receivable and contract assets, Ending balance	2,537
Deferred Revenue - Vertex
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Contract Liabilities, Beginning balance	19,212
Contract Liabilities, Additions	0
Contract Liabilities, Deductions	(10,813)
Contract Liabilities, Ending balance	8,399
Deferred Revenue - Sanofi
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Contract Liabilities, Beginning balance	81,822
Contract Liabilities, Additions	9,052
Contract Liabilities, Deductions	(36,013)
Contract Liabilities, Ending balance	$ 54,861