Collaborations - Change in Accounts Receivable, Contract Asset and Liabilities (Details) $ in Thousands	9 Months Ended
	Sep. 30, 2022 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Accounts receivable and contract assets, Beginning balance	$ 135
Accounts receivable and contract assets, Additions	10,283
Accounts receivable and contract assets, Deductions	(7,536)
Accounts receivable and contract assets, Ending balance	2,882
Contract Liabilities, Beginning balance	101,034
Contract Liabilities, Additions	6,515
Contract Liabilities, Deductions	(30,687)
Contract Liabilities, Ending balance	76,862
Billed Receivables - Sanofi
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Accounts receivable and contract assets, Beginning balance	0
Accounts receivable and contract assets, Additions	3,768
Accounts receivable and contract assets, Deductions	(3,768)
Accounts receivable and contract assets, Ending balance	0
Unbilled Receivables - Sanofi
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Accounts receivable and contract assets, Beginning balance	135
Accounts receivable and contract assets, Additions	6,515
Accounts receivable and contract assets, Deductions	(3,768)
Accounts receivable and contract assets, Ending balance	2,882
Deferred Revenue - Vertex
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Contract Liabilities, Beginning balance	19,212
Contract Liabilities, Additions	0
Contract Liabilities, Deductions	(8,608)
Contract Liabilities, Ending balance	10,604
Deferred Revenue - Sanofi
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Contract Liabilities, Beginning balance	81,822
Contract Liabilities, Additions	6,515
Contract Liabilities, Deductions	(22,079)
Contract Liabilities, Ending balance	$ 66,258