Collaborations - Change in Accounts Receivable, Contract Asset and Liabilities (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2022 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Accounts receivable and contract assets, Beginning balance	$ 135
Accounts receivable and contract assets, Additions	5,031
Accounts receivable and contract assets, Deductions	(2,796)
Accounts receivable and contract assets, Ending balance	2,370
Contract Liabilities, Beginning balance	101,034
Contract Liabilities, Additions	3,633
Contract Liabilities, Deductions	(21,136)
Contract Liabilities, Ending balance	83,531
Billed Receivables - Sanofi
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Accounts receivable and contract assets, Beginning balance	0
Accounts receivable and contract assets, Additions	1,398
Accounts receivable and contract assets, Deductions	(1,398)
Accounts receivable and contract assets, Ending balance	0
Unbilled Receivables - Sanofi
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Accounts receivable and contract assets, Beginning balance	135
Accounts receivable and contract assets, Additions	3,633
Accounts receivable and contract assets, Deductions	(1,398)
Accounts receivable and contract assets, Ending balance	2,370
Deferred Revenue - Vertex
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Contract Liabilities, Beginning balance	19,212
Contract Liabilities, Additions
Contract Liabilities, Deductions	(6,111)
Contract Liabilities, Ending balance	13,101
Deferred Revenue - Sanofi
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Contract Liabilities, Beginning balance	81,822
Contract Liabilities, Additions	3,633
Contract Liabilities, Deductions	(15,025)
Contract Liabilities, Ending balance	$ 70,430