Organization and Nature of Business - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands	Jul. 06, 2021	Aug. 25, 2020	Mar. 31, 2022	Dec. 31, 2021
Organization and Nature of Business [Line Items]
Accumulated deficit			$ 265,666	$ 228,982
Cash, cash equivalents and marketable securities			$ 523,300
Initial Public Offering
Organization and Nature of Business [Line Items]
Stock Issued During Period, Shares, New Issues		9,987,520
Common stock per share		$ 20.00
Gross proceeds from issuance initial public offering		$ 199,800
Private Placement | Vertex Pharmaceuticals Incorporated
Organization and Nature of Business [Line Items]
Stock Issued During Period, Shares, New Issues	49,928	676,354
Common stock per share	$ 47.00	$ 20.00
Aggregate proceeds from issuance of private placement	$ 2,300	$ 13,500
Underwriters
Organization and Nature of Business [Line Items]
Stock Issued During Period, Shares, New Issues	713,250	1,302,720
Follow-on Offering
Organization and Nature of Business [Line Items]
Net proceeds from sale of common stock in public offering	$ 257,000
Stock Issued During Period, Shares, New Issues	5,468,250
Common stock per share	$ 47.00