Collaborations - Change in Accounts Receivable, Contract Asset and Liabilities (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2021 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Accounts receivable and contract assets, Beginning balance	$ 1,433
Accounts receivable and contract assets, Additions	7,669
Accounts receivable and contract assets, Deductions	(8,967)
Accounts receivable and contract assets, Ending balance	135
Contract Liabilities, Beginning balance	170,390
Contract Liabilities, Additions	3,475
Contract Liabilities, Deductions	(72,831)
Contract Liabilities, Ending balance	101,034
Billed Receivables - Sanofi
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Accounts receivable and contract assets, Beginning balance	577
Accounts receivable and contract assets, Additions	4,195
Accounts receivable and contract assets, Deductions	(4,772)
Unbilled Receivables - Sanofi
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Accounts receivable and contract assets, Beginning balance	856
Accounts receivable and contract assets, Additions	3,474
Accounts receivable and contract assets, Deductions	(4,195)
Accounts receivable and contract assets, Ending balance	135
Deferred Revenue - Vertex
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Contract Liabilities, Beginning balance	37,748
Contract Liabilities, Deductions	(18,536)
Contract Liabilities, Ending balance	19,212
Deferred Revenue - Sanofi
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Contract Liabilities, Beginning balance	132,642
Contract Liabilities, Additions	3,475
Contract Liabilities, Deductions	(54,295)
Contract Liabilities, Ending balance	$ 81,822