X0206 3 2020-06-16 0 0001727196 Scholar Rock Holding Corp SRRK 0001815432 Carven Gregory John 620 MEMORIAL DRIVE, 2ND FLOOR CAMBRIDGE MA 02139 0 1 0 0 Head of Research Common Stock 45215 D Stock Option (Right to Buy) 5.77 2028-02-20 Common Stock 40283 D Stock Option (Right to Buy) 14.00 2028-05-23 Common Stock 10054 D Stock Option (Right to Buy) 15.11 2029-01-31 Common Stock 34000 D Stock Option (Right to Buy) 13.52 2030-02-06 Common Stock 38813 D Stock Option (Right to Buy) 18.40 2030-05-29 Common Stock 50000 D This option vests quarterly over four (4) years. 22,659 shares have vested to date and the remainder will vest on a quarterly basis through February 13, 2022. This option vests quarterly over four (4) years. 5,027 shares have vested to date and the remainder will vest on a quarterly basis through May 29, 2022. This option vests quarterly over four (4) years. 10,625 shares have vested to date and the remainder will vest on a quarterly basis through December 31, 2022. This option vests quarterly over four (4) years. 2,425 shares have vested to date and the remainder will vest on a quarterly basis through January 1, 2024. This option vests quarterly over four (4) years. The option will begin vesting on August 29, 2020 and the remainder will vest on a quarterly basis through May 29, 2024. /s/ Junlin Ho, Attorney-in-Fact for Gregory J. Carven 2020-06-18