X0306 4 2021-03-01 0 0001539029 Clearside Biomedical, Inc. CLSD 0001815426 Ciulla Thomas C/O CLEARSIDE BIOMEDICAL, INC. 900 NORTH POINT PARKWAY, SUITE 200 ALPHARETTA GA 30005 0 1 0 0 Chief Medical Officer Employee Stock Option (right to buy) 5.04 2021-03-01 4 A 0 40000 0.00 A 2028-10-24 Common Stock 40000 40000 D On October 24, 2018, the reporting person was granted an option to purchase 40,000 that vests in full based on the satisfaction of certain performance criteria. The performance criteria were met on March 1, 2021, resulting in the vesting of the option full. /s/ Mark Ballantyne, Attorney-in-Fact 2021-03-03