X0306 4 2021-01-18 0 0001539029 Clearside Biomedical, Inc. CLSD 0001815426 Ciulla Thomas C/O CLEARSIDE BIOMEDICAL, INC. 900 NORTH POINT PARKWAY, SUITE 200 ALPHARETTA GA 30005 0 1 0 0 Chief Medical Officer Common Stock 2021-01-18 4 A 0 103125 0.00 A 253122 D Stock Option (Right to Buy) 4.01 2021-01-18 4 A 0 209375 0.00 A 2031-01-18 Common Stock 209375 209375 D These shares are represented by restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of common stock of the Issuer. The shares underlying the RSU vest in 4 equal annual installments on each of January 18, 2022, January 18, 2023, January 18, 2024 and January 18, 2025, subject to the Reporting Person's continuous service as of each such vesting date, and subject to accelerated vesting in specified circumstances. Includes 4,997 shares acquired under the Issuer's employee stock purchase plan on December 31, 2020. One-fourth of the shares underlying this option vest on January 18, 2022 and the balance of the shares vest in a series of 36 successive equal monthly installments thereafter, subject to the reporting person's continuous service as of each such vesting date. /s/ Mark Ballantyne, Attorney-in-Fact 2021-01-20