X0306 4 2023-02-23 0 0001802768 Royalty Pharma plc RPRX 0001814899 Lloyd George W. C/O ROYALTY PHARMA PLC 110 EAST 59TH STREET NEW YORK NY 10022 0 1 0 0 EVP, Investments & CLO Class A Ordinary Shares 2023-02-23 4 S 0 25000 37.2663 D 325000 I By GWL 2014 G, LLC Class A Ordinary Shares 495860 I By GWL 2013 NG, LLC Class A Ordinary Shares 273960 I By IRA Class A Ordinary Shares 130000 I By GWL 2020 G, LLC Class A Ordinary Shares 3000 D Class A Ordinary Shares 4011 I By Spouse The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.19 to $37.37 per share. The holder undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Sean Weisberg, as Attorney-in-Fact for George W. Lloyd 2023-02-27