<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001814693</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001590560</issuerCik>
      <issuerName>uniQure N.V.</issuerName>
      <secFileNumber>001-36294</secFileNumber>
      <issuerAddress>
        <com:street1>PAASHEUVELWEG 25A</com:street1>
        <com:city>AMSTERDAM</com:city>
        <com:stateOrCountry>P7</com:stateOrCountry>
        <com:zipCode>1105 BP</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>1-339-970-7000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Potts Jeannette</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>CHIEF LEGAL OFFICER</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>ORDINARY SHARES</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>CITIGROUP GLOBAL MARKETS</name>
        <address>
          <com:street1>390 GREENWICH ST</com:street1>
          <com:city>NEW YORK</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10013</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>5237</noOfUnitsSold>
      <aggregateMarketValue>144886.32</aggregateMarketValue>
      <noOfUnitsOutstanding>63067485</noOfUnitsOutstanding>
      <approxSaleDate>06/15/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>ORDINARY SHARES</securitiesClassTitle>
      <acquiredDate>06/15/2026</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK UNITS VESTING</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>UNIQURE NV</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>15702</amountOfSecuritiesAcquired>
      <paymentDate>06/15/2026</paymentDate>
      <natureOfPayment>Services Rendered</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Shares being sold are pursuant to the vesting and settlement of equity awards.</remarks>
    <noticeSignature>
      <noticeDate>06/15/2026</noticeDate>
      <signature>CONFORMED SIGNATURE ON FILE</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
