X0508 4 2025-08-04 0 0001814114 Orchestra BioMed Holdings, Inc. OBIO 0001292834 Hochman David P C/O ORCHESTRA BIOMED HOLDINGS, INC. 150 UNION SQUARE DRIVE NEW HOPE PA 18938 1 1 0 0 See Remarks 0 Common Stock, par value $0.0001 per share ("Common Stock") 2025-08-04 4 P 0 20000 2.75 A 349331 I By the DPH 2008 Trust Common Stock 545460 D Common Stock 2000 I By the Solomon Ascher Hochman 2019 Trust Common Stock 2000 I By the Hannah Hochman 2019 Trust Common Stock 2000 I By the Judah Herman Hochman 2019 Trust Common Stock 3140 I By the NSH 2008 Family Trust These shares were purchased in an underwritten public offering of the Issuer at the public offering price of $2.75 per share. Chief Executive Officer and Chairperson /s/ Andrew Taylor, Attorney-in-Fact 2025-08-04