X0206 3/A 2020-06-18 2020-06-18 0 0001580063 PROGENITY, INC. PROG 0001813865 Gianakopoulos George C/O PROGENITY, INC. 4330 LA JOLLA VILLAGE DRIVE, SUITE 200 SAN DIEGO CA 92122 0 1 0 0 Senior Vice President of Sales Common Stock 23499 D Stock Option (Right to Buy) 6.49 2024-09-22 Common Stock 13759 D Stock Option (Right to Buy) 10.75 2025-02-01 Common Stock 4046 D Stock Option (Right to Buy) 12.54 2026-02-24 Common Stock 4855 D Stock Option (Right to Buy) 9.88 2027-02-23 Common Stock 6474 D Stock Option (Right to Buy) 9.88 2028-02-22 Common Stock 5664 D Stock Option (Right to Buy) 9.88 2029-04-15 Common Stock 6473 D Stock Option (Right to Buy) 9.88 2029-11-15 Common Stock 8092 D Stock Option (Right to Buy) 9.76 2030-03-04 Common Stock 2787 D Stock Option (Right to Buy) 9.76 2030-03-04 Common Stock 10520 D Includes 17,025 restricted stock units ("RSUs"), 3,332 of which have vested. Subject to the Reporting Person's continued service to the Issuer, (i) 1,650 RSUs will vest on March 4, 2021 and (ii) 1,315 RSUs will vest on May 15, 2021. All other unvested RSUs will vest in semi-annual installments, subject to the Reporting Person's continued service to the Issuer, (i) beginning on February 15, 2021 and ending on August 15, 2022 for 1,181 RSUs, (ii) beginning on February 15, 2021 and ending on August 15, 2023 for 2,228 RSUs, (iii) beginning on February 15, 2021 and ending on February 15, 2024 for 3,374 RSUs, and (iv) beginning on November 15, 2021 and ending on May 15, 2024 for 3,945 RSUs. This option represents the right to purchase 13,759 shares of the Issuer's common stock, all of which have vested. This option represents the right to purchase 4,046 shares of the Issuer's common stock, all of which have vested. This option represents the right to purchase 4,855 shares of the Issuer's common stock, all of which have vested. This option represents the right to purchase a total of 6,474 shares of the Issuer's common stock, 5,259 of which have vested, with the remaining shares vesting in equal monthly installments through February 23, 2021, subject to the Reporting Person's continued service to the Issuer. This option represents the right to purchase a total of 5,664 shares of the Issuer's common stock, 3,304 of which have vested, with the remaining shares vesting in equal monthly installments through February 15, 2022, subject to the Reporting Person's continued service to the Issuer. This option represents the right to purchase a total of 6,473 shares of the Issuer's common stock, 2,022 of which have vested, with the remaining shares vesting in equal monthly installments through March 15, 2023, subject to the Reporting Person's continued service to the Issuer. This option represents the right to purchase a total of 8,092 shares of the Issuer's common stock, 1,346 of which have vested, with the remaining shares vesting in equal monthly installments through October 15, 2023, subject to the Reporting Person's continued service to the Issuer. This option represents the right to purchase 2,787 shares of the Issuer's common stock, all of which have vested. This option represents the right to purchase a total of 10,520 shares of the Issuer's common stock, 877 of which have vested, with the remaining shares vesting in equal monthly installments through February 4, 2024, subject to the Reporting Person's continued service to the Issuer. This amendment is being filed to correct the number of RSUs vested as of June 18, 2020, the number of RSUs that will vest from February 15, 2021 to February 15, 2022, the number of RSUs that will vest from February 15, 2021 to August 15, 2023, the number of RSUs that will vest from February 15, 2021 to February 15, 2024, the number of shares vested as of June 18, 2020 for the option reported in row 4 of Table II, the number of shares underlying the derivative security and final vesting date for the option reported in row 5 of Table II, and the number of shares underlying the derivative security, the number of shares vested as of June 18, 2020 and the final vesting dates for the options reported in rows 6, 7 and 9 of Table II. /s/ Regan Lauer, Attorney-in-fact for George Gianakopoulos 2020-08-24