<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2021-07-22</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001841804</issuerCik>
        <issuerName>INSTRUCTURE HOLDINGS, INC.</issuerName>
        <issuerTradingSymbol>INST</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001813487</rptOwnerCik>
            <rptOwnerName>THOMA BRAVO UGP, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O THOMA BRAVO, L.P.</rptOwnerStreet1>
            <rptOwnerStreet2>150 NORTH RIVERSIDE PLAZA, SUITE 2800</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60606</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001874229</rptOwnerCik>
            <rptOwnerName>THOMA BRAVO PARTNERS XIII, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O THOMA BRAVO, L.P.</rptOwnerStreet1>
            <rptOwnerStreet2>150 NORTH RIVERSIDE PLAZA, SUITE 2800</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60606</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001744119</rptOwnerCik>
            <rptOwnerName>THOMA BRAVO FUND XIII, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O THOMA BRAVO, L.P.</rptOwnerStreet1>
            <rptOwnerStreet2>150 NORTH RIVERSIDE PLAZA, SUITE 2800</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60606</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001744118</rptOwnerCik>
            <rptOwnerName>THOMA BRAVO FUND XIII-A, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O THOMA BRAVO, L.P.</rptOwnerStreet1>
            <rptOwnerStreet2>150 NORTH RIVERSIDE PLAZA, SUITE 2800</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60606</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001759152</rptOwnerCik>
            <rptOwnerName>THOMA BRAVO EXECUTIVE FUND XIII, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O THOMA BRAVO, L.P.</rptOwnerStreet1>
            <rptOwnerStreet2>150 NORTH RIVERSIDE PLAZA, SUITE 2800</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60606</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>122065804</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Consists of 1,073,324 shares held directly by Thoma Bravo Executive Fund XIII, L.P. (&quot;TB Exec Fund&quot;), 56,619,128 shares held directly by Thoma Bravo Fund XIII, L.P. (&quot;TB Fund XIII&quot;), and 64,373,352 shares held directly by Thoma Bravo Fund XIII-A, L.P. (&quot;TB Fund XIII-A&quot;).</footnote>
        <footnote id="F2">Thoma Bravo Partners XIII, L.P. (&quot;TB Partners XIII&quot;) is the general partner of each of TB Exec Fund, TB Fund XIII and TB Fund XIII-A. Thoma Bravo UGP, LLC (&quot;TB UGP&quot;) is the ultimate general partner of TB Partners XIII. By virtue of the relationships described in this footnote, TB UGP and TB Partners XIII may be deemed to exercise voting and dispositive power with respect to the shares held directly by TB Exec Fund, TB Fund XIII and TB Fund XIII-A. Each of TB UGP and TB Partners XIII disclaims beneficial ownership of the shares owned by TB Exec Fund, TB Fund XIII, and TB Fund XIII-A except to the extent of its pecuniary interest therein.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Holden Spaht, Managing Partner of Thoma Bravo, UGP, LLC</signatureName>
        <signatureDate>2021-07-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Holden Spaht, Managing Partner of Thoma Bravo, UGP, LLC, the General Partner of Thoma Bravo Partners XIII, L.P.</signatureName>
        <signatureDate>2021-07-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Holden Spaht, Managing Partner of Thoma Bravo, UGP, LLC, the ultimate GP of Thoma Bravo Fund XIII, L.P.</signatureName>
        <signatureDate>2021-07-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Holden Spaht, Managing Partner of Thoma Bravo, UGP, LLC, the ultimate GP of  Thoma Bravo Fund XIII-A, L.P.</signatureName>
        <signatureDate>2021-07-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Holden Spaht, Managing Partner of Thoma Bravo, UGP, LLC, the ultimate GP of Thoma Bravo Executive Fund XIII, L.P.</signatureName>
        <signatureDate>2021-07-22</signatureDate>
    </ownerSignature>
</ownershipDocument>
