X0306 4 2022-06-21 0001520262 Alkermes plc. ALKS 0001813312 Nichols Christian Todd 852 WINTER ST. WALTHAM MA 02451 1 SVP, Chief Commercial Officer Ordinary Shares 2022-06-21 4 S 0 7474 28.2584 D 21035 D This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.00 to $28.595. Full information regarding the number of shares sold at each separate price can be provided to the issuer, any security holder of the issuer or the SEC staff upon request. /s/ Shantale Greenson, attorney-in-fact for Christian Todd Nichols 2022-06-21