144 0001818261 XXXXXXXX LIVE 0001812364 RELAY THERAPEUTICS, INC. 001-39385 60 Hampshire Street Cambridge MA 02139 617-370-8837 THOMAS CATINAZZO Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

204880 3253494.40 191586165 06/22/2026 NASDAQ Common 06/22/2026 Exercise of Stock Options Issuer N 151729 06/22/2026 Cash Common 04/29/2025 Restricted Stock Units Issuer N 29196 04/29/2025 N/A Common 01/29/2025 Performance Stock Units Issuer N 23955 01/29/2025 N/A N 10b5-1 Sales for THOMAS J CATINAZZO

60 Hampshire Street Cambridge MA 02139

Common 05/14/2026 17717 227808.73 THOMAS J CATINAZZO

60 Hampshire Street Cambridge MA 02139

Common 04/28/2026 972 14375.88 10b5-1 Sales for THOMAS J CATINAZZO

60 Hampshire Street Cambridge MA 02139

Common 04/09/2026 1800 27000.00 10b5-1 Sales for THOMAS J CATINAZZO

60 Hampshire Street Cambridge MA 02139

Common 04/07/2026 17717 230577.90 The securities to be sold were acquired upon the vesting of restricted stock units during the period of 04/29/2025 through 07/28/2025. 06/22/2026 10/30/2025 /s/ Thomas Catinazzo