X0306 4 2022-04-28 0 0001812364 Relay Therapeutics, Inc. RLAY 0001709772 Bergstrom Donald A C/O RELAY THERAPEUTICS, INC. 399 BINNEY STREET, 2ND FLOOR CAMBRIDGE MA 02139 0 1 0 0 President, R&D Common Stock 2022-04-28 4 S 0 1811 25.57 D 92493 D Common Stock 2022-05-02 4 M 0 13000 4.12 A 105493 D Common Stock 2022-05-02 4 S 0 13000 24.62 D 92493 D Stock Option (Right to Buy) 4.12 2022-05-02 4 M 0 13000 0.00 D 2028-04-09 Common Stock 13000 186456 D Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 4,059 shares of restricted stock units ("RSUs") on April 27, 2022. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs. Includes 87,141 shares underlying RSUs. The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 7, 2022. This transaction was executed in multiple trades at prices ranging from $23.09 to $25.00. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Twenty-five percent (25%) of the shares underlying this option vested on April 2, 2019 and the remainder shall vest in equal quarterly installments over the remaining thirty-six (36) months, subject to the reporting person's continued employment through each vesting date. /s/ Brian Adams, as attorney-in-fact 2022-05-02