X0306 4 2022-01-27 0 0001812364 Relay Therapeutics, Inc. RLAY 0001709772 Bergstrom Donald A C/O RELAY THERAPEUTICS, INC. 399 BINNEY STREET, 2ND FLOOR CAMBRIDGE MA 02139 0 1 0 0 President, R&D Common Stock 2022-01-27 4 A 0 64950 0.00 A 109920 D Stock Option (Right to Buy) 20.38 2022-01-27 4 A 0 129900 0.00 A 2032-01-26 Common Stock 129900 129900 D Represents restricted stock units ("RSUs") granted to the reporting person pursuant to the Issuer's 2020 Stock Option and Incentive Plan. Each RSU represents a contingent right to receive one share of the Issuer's common stock upon vesting. The RSUs shall vest in sixteen (16) equal quarterly installments commencing on January 27, 2022, subject to the reporting person's continued service with the Issuer through each vesting date. Includes 93,387 shares underlying RSUs. The shares underlying this stock option shall vest in sixteen (16) equal quarterly installments commencing on January 27, 2022, subject to the reporting person's continued service with the Issuer through each vesting date. /s/ Brian Adams, as Attorney-in-Fact 2022-01-31