X0306 4 2021-12-31 0 0001812364 Relay Therapeutics, Inc. RLAY 0001636994 Adams Brian C/O RELAY THERAPEUTICS, INC. 399 BINNEY STREET, 2ND FLOOR CAMBRIDGE MA 02139 0 1 0 0 General Counsel Common Stock 2021-12-31 5 A 0 E 658 26.10 A 25647 D The shares were acquired under the Relay Therapeutics, Inc. 2020 Employee Stock Purchase Plan ("ESPP") in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c). The reporting person is voluntarily reporting this transaction. In accordance with the ESPP, these shares were purchased at a price equal to 85% of the closing price of the Issuer's common stock on December 31, 2021. Includes 12,895 shares underlying RSUs. /s/ Brian Adams 2022-01-07