X0306 4 2021-03-26 0 0001812364 Relay Therapeutics, Inc. RLAY 0001636994 Adams Brian C/O RELAY THERAPEUTICS, INC. 399 BINNEY STREET, 2ND FLOOR CAMBRIDGE MA 02139 0 1 0 0 General Counsel Common Stock 2021-03-26 4 A 0 15870 0.00 A 25870 D Stock Option (Right to Buy) 34.25 2021-03-26 4 A 0 31740 0.00 A 2031-03-25 Common Stock 31740 31740 D Represents restricted stock units ("RSUs") granted to the reporting person pursuant to the Issuer's 2020 Stock Option and Incentive Plan. Each RSU represents a contingent right to receive one share of the Issuer's common stock upon vesting. The RSUs shall vest in sixteen (16) equal quarterly installments after March 26, 2021, subject to the reporting person's continued service with the Issuer through each vesting date. The shares underlying this stock option shall vest in sixteen (16) equal quarterly installments after March 26, 2021, subject to the reporting person's continued service with the Issuer through each vesting date. /s/ Brian Adams 2021-03-26