Commitments and Contingencies - Additional Information (Detail) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Commitments and Contingencies Disclosure [Line Items]
Accrued expenses	$ 22,108,000		$ 22,108,000		$ 13,557,000
DE Shaw Research [Member]
Commitments and Contingencies Disclosure [Line Items]
Research and development expense	2,300,000	$ 2,100,000	4,700,000	$ 3,900,000
Accrued expenses	300,000		300,000		0
Prepaid balance	0		0		4,400,000
DE Shaw Research [Member] | Lease Agreement
Commitments and Contingencies Disclosure [Line Items]
Milestone payment Due	0		0		0
Other Third Parties [Member]
Commitments and Contingencies Disclosure [Line Items]
Research and development expense	1,600,000	$ 700,000	2,600,000	$ 1,100,000
Other Third Parties [Member] | License Agreement Terms [Member]
Commitments and Contingencies Disclosure [Line Items]
Milestone payment Due	$ 0		$ 0		$ 0