Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Summary of Reconciliation of Expected Income Tax (Benefit) Computed Using Federal Statutory Income Tax Rate to Effective Income Tax Rate

A reconciliation of the expected income tax (benefit) computed using the federal statutory income tax rate to the Company’s effective income tax rate is as follows for the years ended December 31, 2021, 2020 and 2019:

	December 31,
	2021			2020			2019
Income tax computed at federal statutory rate		21.0	%		21.0	%		21.0	%
State taxes, net of federal benefit		5.7	%		5.7	%		7.0	%
Change in valuation allowance		(20.5	)%		(27.3	)%		(31.0	)%
IPR&D		(7.0	)%		—			—
R&D credit carryovers		2.2	%		7.6	%		4.1	%
Stock-based compensation		(0.4	)%		(6.7	)%		(0.9	)%
Permanent differences		(1.0	)%		(0.3	)%		(0.2	)%
Total		0.0	%		0.0	%		0.0	%

Summary of Deferred Tax Assets and Liabilities

The Company’s deferred tax assets and liabilities at December 31, 2021 and 2020, consist of the following:

	December 31,
	2021			2020
Deferred tax assets:
Net operating losses	$	108,800		$	48,832
Tax credit carryforwards		18,288			10,270
Lease liability		6,010			6,430
Intangibles		1,859			1,469
Stock-based compensation		8,374			4,496
Depreciation and amortization		477			230
Other		4,304			14
Total gross deferred tax asset		148,112			71,741
Valuation allowance		(142,674	)		(65,813	)
Net deferred tax asset		5,438			5,928
Deferred tax liability
Operating lease assets		(5,438	)		(5,928	)
Total deferred tax liability		(5,438	)		(5,928	)
	$	—		$	—