SCHEDULE 13G/A 0000919574-24-001483 0001534261 XXXXXXXX LIVE 2 Common Stock, par value $0.001 per share 12/31/2025 0001812364 Relay Therapeutics, Inc. 75943R102 399 Binney Street 2nd Floor Cambridge MA 02139 Rule 13d-1(c) CASDIN CAPITAL, LLC DE 0.00 13003574.00 0.00 13003574.00 13003574.00 N 7.5 IA CASDIN PARTNERS MASTER FUND, L.P. E9 0.00 12585000.00 0.00 12585000.00 12585000.00 N 7.3 PN CASDIN PARTNERS GP, LLC DE 0.00 13003574.00 0.00 13003574.00 13003574.00 N 7.5 OO ELI CASDIN X1 0.00 13003574.00 0.00 13003574.00 13003574.00 N 7.5 HC IN Relay Therapeutics, Inc. 60 Hampshire Street, Cambridge, MA 02139 Casdin Capital, LLC Casdin Partners Master Fund, L.P. Casdin Partners GP, LLC Eli Casdin Casdin Capital, LLC 1350 Avenue of the Americas, Suite 2600 New York, New York 10019 Casdin Partners Master Fund, L.P. 1350 Avenue of the Americas, Suite 2600 New York, New York 10019 Casdin Partners GP, LLC 1350 Avenue of the Americas, Suite 2600 New York, New York 10019 Eli Casdin 1350 Avenue of the Americas, Suite 2600 New York, New York 10019 Casdin Capital, LLC - Delaware Casdin Partners Master Fund, L.P. - Cayman Islands Casdin Partners GP, LLC - Delaware Eli Casdin - United States Y Casdin Capital, LLC - 13,003,574 Casdin Partners Master Fund, L.P. - 12,585,000 Casdin Partners GP, LLC - 13,003,574 Eli Casdin - 13,003,574 Casdin Capital, LLC - 7.5% Casdin Partners Master Fund, L.P. - 7.3% Casdin Partners GP, LLC - 7.5% Eli Casdin - 7.5% Casdin Capital, LLC - 0 Casdin Partners Master Fund, L.P. - 0 Casdin Partners GP, LLC - 0 Eli Casdin - 0 Casdin Capital, LLC - 13,003,574 Casdin Partners Master Fund, L.P. - 12,585,000 Casdin Partners GP, LLC - 13,003,574 Eli Casdin - 13,003,574 Casdin Capital, LLC - 0 Casdin Partners Master Fund, L.P. - 0 Casdin Partners GP, LLC - 0 Eli Casdin - 0 Casdin Capital, LLC - 13,003,574 Casdin Partners Master Fund, L.P. - 12,585,000 Casdin Partners GP, LLC - 13,003,574 Eli Casdin - 13,003,574 Y N All of the securities reported in this Schedule 13G Amendment No. 2 are directly owned by advisory clients of Casdin Capital, LLC. None of those advisory clients, other than Casdin Partners Master Fund, L.P., may be deemed to beneficially own more than 5% of the Common Stock, par value $0.001 per share. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit A - Joint Filing Agreement CASDIN CAPITAL, LLC By: /s/ Eli Casdin 02/17/2026 CASDIN PARTNERS MASTER FUND, L.P. By: /s/ Eli Casdin 02/17/2026 CASDIN PARTNERS GP, LLC By: /s/ Eli Casdin 02/17/2026 ELI CASDIN By: /s/ Eli Casdin 02/17/2026 * Each Reporting Person disclaims beneficial ownership of the reported securities except to the extent of his, her or its pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. To the extent that "ownership of 5 percent or less of a class" was indicated in Item 5, such response only applies to the Reporting Person(s) that indicated elsewhere herein that it beneficially owns five percent (5%) or less of the class.