X0306 4 2021-04-01 0 0001680581 Fulcrum Therapeutics, Inc. FULC 0001811904 Dunn Judith C/O FULCRUM THERAPEUTICS, INC. 26 LANDSDOWNE STREET CAMBRIDGE MA 02139 0 1 0 0 See Remarks Stock Option (right to buy) 12.00 2021-04-01 4 A 0 215000 0.00 A 2031-03-31 Common Stock 215000 215000 D This option was granted on April 1, 2021 and is scheduled to vest 25% on the first anniversary of the vesting commencement date of April 1, 2021. The remainder of the shares underlying the grant shall vest in equal quarterly installments over the following three years until the fourth anniversary of the vesting commencement date, subject to continued service. President, Research & Development /s/ Peter Thomson, as attorney-in-fact for Judith A. Dunn 2021-04-02