X0306 4 2021-02-24 0 0001797336 Ayala Pharmaceuticals, Inc. AYLA 0001811354 Gordon Gary B. OPPENHEIMER 4 REHOVOT L3 7670104 ISRAEL 0 1 0 0 Chief Medical Officer Common Stock 2021-02-24 4 M 0 3000 5.16 A 11520 D Common Stock 2021-02-24 4 S 0 3000 17.4617 D 8520 D Stock Option 5.16 2021-02-24 4 M 0 3000 0.00 D 2029-09-19 Common Stock 3000 89000 D The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. This option vested and became exercisable as to 25% of the underlying shares of common stock on August 1, 2020 and will become vested and exercisable as to the remainder of the shares in 12 equal quarterly installments thereafter. /s/ Roni Mamluk, Ph.D., Attorney-in-Fact for Gary B. Gordon 2021-02-26