X0508 4 2023-11-20 0 0001811115 Renalytix plc RNLX 0001415965 Doran Howard JR C/O RENALYTIX PLC FINSGATE, 5-7 CRANWOOD STREET LONDON X0 EC1V 9EE UNITED KINGDOM 0 1 0 0 Chief Business Officer 0 Employee Stock Option (right to buy) 0.304 2023-11-20 4 A 0 300000 0.00 A 2033-11-19 Ordinary Shares 300000 300000 D The exercise price is 0.245 pounds sterling. The U.S. dollar equivalent of the exercise price is $0.304 using the Bank of England rate as of November 17, 2023 (1.00 pound sterling = $1.243). One third (1/3rd) of the shares subject to the option award shall vest on September 1, 2024, and one eighth (1/8th) of the remaining shares subject to the option award shall vest in equal quarterly installments thereafter, subject to the Reporting Person's continuous service. /s/ Katie Kazem, Attorney-in-Fact 2023-11-22