X0306 4 2021-12-15 0 0001811063 Nuvation Bio Inc. NUVB 0001641354 Omega Fund V, L.P. 888 BOYLSTON STREET, SUITE 1111 BOSTON MA 02199 0 0 1 0 0001528383 Omega Fund IV GP, L.P. 888 BOYLSTON STREET, SUITE 1111 BOSTON MA 02199 0 0 1 0 0001641348 Omega Fund V GP Manager, Ltd. 888 BOYLSTON STREET, SUITE 1111 BOSTON MA 02199 0 0 1 0 Common Stock 2021-12-15 4 S 0 500000 10.07 D 22957340 D The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. The reported securities are held directly by Omega Fund V, L.P. ("Omega V"). The reported securities may be deemed to be beneficially owned by each of Omega Fund V GP, L.P. ("Omega V GP"), as the general partner of Omega V, and Omega Fund V GP Manager, Ltd. ("Omega V GP Manager"), as the general partner of Omega V GP. Otello Stampacchia, Claudio Nessi and Anne-Mari Paster are all the shareholders and directors of Omega V GP Manager and have shared voting and investment power over the shares held by Omega V. Each of Omega V GP, Omega Fund V GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. /s/ Anne-Mari Paster, as an authorized signatory of each Reporting Person 2021-12-17