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          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TScan Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>TScan Therapeutics Inc</title>
        <cusip>89854M101</cusip>
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          <isin value="US89854M1018"/>
          <ticker value="TCRX"/>
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        <curCd>USD</curCd>
        <valUSD>1518028.20000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Plains GP Holdings LP</name>
        <lei>549300O56BSKRD8FAM12</lei>
        <title>Plains GP Holdings LP</title>
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          <isin value="US72651A2078"/>
          <ticker value="PAGP"/>
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        <balance>1272360.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>24721954.80000000</valUSD>
        <pctVal>38.06142424657</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Abeona Therapeutics Inc</name>
        <lei>54930002Z8PIJRCB4576</lei>
        <title>Abeona Therapeutics Inc</title>
        <cusip>00289Y206</cusip>
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          <isin value="US00289Y2063"/>
          <ticker value="ABEO"/>
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        <curCd>USD</curCd>
        <valUSD>3172757.12000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CHINOOK THERAPEUTICS INC CVR</name>
        <lei>N/A</lei>
        <title>CHINOOK THERAPEUTICS INC CVR</title>
        <cusip>000000000</cusip>
        <identifiers>
          <ticker value="KDNY"/>
          <other otherDesc="INTERNAL" value="169CVR016"/>
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        <balance>25000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>2500.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Achieve Life Sciences Inc</name>
        <lei>549300V82ZKZDTAU0A46</lei>
        <title>Achieve Life Sciences Inc</title>
        <cusip>004468500</cusip>
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          <isin value="US0044685008"/>
          <ticker value="ACHV"/>
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        <balance>2551178.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>5765662.28000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Phathom Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Phathom Pharmaceuticals Inc</title>
        <cusip>71722W107</cusip>
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          <isin value="US71722W1071"/>
          <ticker value="PHAT"/>
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        <balance>521935.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>5005356.65000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Athira Pharma Inc</name>
        <lei>529900CSS4S4X8VY5C81</lei>
        <title>Athira Pharma Inc</title>
        <cusip>04746L104</cusip>
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          <isin value="US04746L1044"/>
          <ticker value="ATHA"/>
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        <balance>1492792.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>450823.18000000</valUSD>
        <pctVal>0.694078298135</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MORGAN STANLEY &amp; CO. LLC</name>
        <lei>9R7GPTSO7KV3UQJZQ078</lei>
        <title>Morgan Stanley</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="INTERNAL" value="RRMSN0225"/>
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        <balance>-35125714.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>-35125714.00000000</valUSD>
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        <payoffProfile>Short</payoffProfile>
        <assetCat>RA</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <repurchaseAgrmt>
          <transCat>Reverse repurchase</transCat>
          <notClearedCentCparty isCleared="N">
            <counterpartyInfos>
              <counterpartyInfo lei="9R7GPTSO7KV3UQJZQ078" name="MORGAN STANLEY &amp; CO. LLC"/>
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          <isTriParty>N</isTriParty>
          <repurchaseRt>4.53000000</repurchaseRt>
          <maturityDt>2025-07-02</maturityDt>
          <repurchaseCollaterals>
            <repurchaseCollateral>
              <principalAmt>36000000.00000000</principalAmt>
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              <collateralVal>35125714.00000000</collateralVal>
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              <invstCat>UST</invstCat>
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          </repurchaseCollaterals>
        </repurchaseAgrmt>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Eiger BioPharmaceuticals Inc</name>
        <lei>549300GO4VMIHDKJNU46</lei>
        <title>Eiger BioPharmaceuticals Inc</title>
        <cusip>28249U204</cusip>
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          <isin value="US28249U2042"/>
          <ticker value="EIGRQ"/>
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        <balance>90000.00000000</balance>
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        <curCd>USD</curCd>
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        <pctVal>0.651242289962</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Applied Therapeutics Inc</name>
        <lei>549300KL3IJPHZM2GR04</lei>
        <title>Applied Therapeutics Inc</title>
        <cusip>03828A101</cusip>
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          <ticker value="APLT"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>TELESAT CANADA/TELESAT L</name>
        <lei>N/A</lei>
        <title>Telesat Canada / Telesat LLC</title>
        <cusip>87952VAM8</cusip>
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          <other otherDesc="SEDOL" value="BKDN9P3"/>
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        <balance>6124000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>2297203.89000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <debtSec>
          <maturityDt>2027-10-15</maturityDt>
          <couponKind>Fixed</couponKind>
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          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>MORGAN STANLEY &amp; CO. LLC</name>
        <lei>9R7GPTSO7KV3UQJZQ078</lei>
        <title>Morgan Stanley</title>
        <cusip>000000000</cusip>
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          <other otherDesc="INTERNAL" value="RRMSN0125"/>
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        <balance>-35120240.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>-35120240.00000000</valUSD>
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        <assetCat>RA</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <repurchaseAgrmt>
          <transCat>Reverse repurchase</transCat>
          <notClearedCentCparty isCleared="N">
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          <isTriParty>N</isTriParty>
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      <invstOrSec>
        <name>TELESAT CANADA/TELESAT L</name>
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        <invCountry>CA</invCountry>
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        <fairValLevel>2</fairValLevel>
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          <couponKind>Fixed</couponKind>
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        <securityLending>
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      </invstOrSec>
      <invstOrSec>
        <name>TREASURY BILL</name>
        <lei>254900HROIFWPRGM1V77</lei>
        <title>United States Treasury Bill</title>
        <cusip>912797MG9</cusip>
        <identifiers>
          <isin value="US912797MG92"/>
          <other otherDesc="SEDOL" value="BRJGTS8"/>
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        <balance>36000000.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>DBT</assetCat>
        <issuerCat>UST</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <debtSec>
          <maturityDt>2025-08-07</maturityDt>
          <couponKind>None</couponKind>
          <annualizedRt>0.00000000</annualizedRt>
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        <securityLending>
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      </invstOrSec>
      <invstOrSec>
        <name>FIDELITY INV MMTRSY 1 680</name>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>Delcath Systems Inc</name>
        <lei>549300NVPLITUM6URT02</lei>
        <title>Delcath Systems Inc</title>
        <cusip>24661P807</cusip>
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          <isin value="US24661P8077"/>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2025-08-25</ncom:dateSigned>
      <ncom:nameOfApplicant>Simplify Exchange Traded Funds</ncom:nameOfApplicant>
      <ncom:signature>Paul Kim</ncom:signature>
      <ncom:signerName>Paul Kim</ncom:signerName>
      <ncom:title>Trustee, President and Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
