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          <isin value="US87952VAR78"/>
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        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Achieve Life Sciences Inc</name>
        <lei>549300V82ZKZDTAU0A46</lei>
        <title>Achieve Life Sciences Inc</title>
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          <isin value="US0044685008"/>
          <ticker value="ACHV"/>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Delcath Systems Inc</name>
        <lei>549300NVPLITUM6URT02</lei>
        <title>Delcath Systems Inc</title>
        <cusip>24661P807</cusip>
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          <isin value="US24661P8077"/>
          <ticker value="DCTH"/>
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        <balance>117000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1489410.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Akero Therapeutics Inc</name>
        <lei>549300SI3KG74LBE2955</lei>
        <title>Akero Therapeutics Inc</title>
        <cusip>00973Y108</cusip>
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          <isin value="US00973Y1082"/>
          <ticker value="AKRO"/>
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        <curCd>USD</curCd>
        <valUSD>5894252.32000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CHINOOK THERAPEUTICS INC CVR</name>
        <lei>N/A</lei>
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          <ticker value="KDNY"/>
          <other otherDesc="INTERNAL" value="169CVR016"/>
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        <balance>25000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>38500.00000000</valUSD>
        <pctVal>0.055970089283</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>TELESAT CANADA/TELESAT L</name>
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          <isin value="US87952VAM81"/>
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        <curCd>USD</curCd>
        <valUSD>2663940.00000000</valUSD>
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        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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          <couponKind>Fixed</couponKind>
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        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Phathom Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Phathom Pharmaceuticals Inc</title>
        <cusip>71722W107</cusip>
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          <isin value="US71722W1071"/>
          <ticker value="PHAT"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Madrigal Pharmaceuticals Inc</name>
        <lei>549300CHIMT2EUSNJB60</lei>
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        <cusip>558868105</cusip>
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          <isin value="US5588681057"/>
          <ticker value="MDGL"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MORGAN STANLEY &amp; CO. LLC</name>
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        <title>Morgan Stanley</title>
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        <fairValLevel>2</fairValLevel>
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        <name>Athira Pharma Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MORGAN STANLEY &amp; CO. LLC</name>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>Applied Therapeutics Inc</name>
        <lei>549300KL3IJPHZM2GR04</lei>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>FIDELITY INV MMTRSY 1 680</name>
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        <fairValLevel>1</fairValLevel>
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        <name>MaaT Pharma SACA</name>
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        <invCountry>FR</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>TREASURY BILL</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Syndax Pharmaceuticals Inc</name>
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        <name>Compass Therapeutics Inc</name>
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        <title>Compass Therapeutics Inc</title>
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        <name>Plains GP Holdings LP</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Eiger BioPharmaceuticals Inc</name>
        <lei>549300GO4VMIHDKJNU46</lei>
        <title>Eiger BioPharmaceuticals Inc</title>
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        <fairValLevel>3</fairValLevel>
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      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2025-05-23</ncom:dateSigned>
      <ncom:nameOfApplicant>Simplify Exchange Traded Funds</ncom:nameOfApplicant>
      <ncom:signature>Paul Kim</ncom:signature>
      <ncom:signerName>Paul Kim</ncom:signerName>
      <ncom:title>Trustee, President and Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
