X0306 4 2022-02-16 0 0001327273 Lyra Therapeutics, Inc. LYRA 0001810701 Palasis Maria 480 ARSENAL WAY WATERTOWN MA 02472 1 1 0 0 President & CEO Stock Option 4.21 2022-02-16 4 A 0 175000 0.00 A 2032-02-15 Common Stock 175000 175000 D On February 16, 2022, the Reporting Person was granted an option to purchase 175,000 shares of common stock. The option vests and becomes exercisable as to 58,333 shares underlying the option when the Issuer's market capitalization reaches $250,000,000; (ii) 58,333 shares underlying the option when the Issuer's market capitalization reaches $350,000,000; and (iii) 58,334 shares underlying the option when the Issuer's market capitalization reaches $500,000,000, all subject to the Reporting Person's continued service to the Issuer through each such date. /s/ Jason Cavalier, Attorney-in-Fact for Maria Palasis, Ph.D. 2022-02-18