Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule Components of Loss Before Income Taxes

The U.S. domestic and international components of pre-tax loss for the years ending December 31, 2022, 2021 and 2020 are as follows (in thousands):

	Year Ended December 31,
	2022			2021			2020
United States	$	(111,360	)	$	(30,565	)	$	(9,457	)
International		(12,058	)		(52,919	)		(36,042	)
Loss before income taxes	$	(123,418	)	$	(83,484	)	$	(45,499	)

Schedule of Income Tax Provision (Benefit)

The federal and state provision (benefit) for income taxes consist of the following (in thousands):

	Year Ended December 31,
	2022		2021			2020
Current provision for income taxes:
Federal	$	64	$	(21	)	$	239
State		—		—			2
International		—		—			—
Total current		64		(21	)		241
Deferred tax provision:
Federal		—		—			—
State		—		—			—
International		—		—			—
Total deferred		—		—			—
Provision (benefit) for income taxes	$	64	$	(21	)	$	241

Schedule of Statutory and Effective Income Tax Rate Reconciliation

A reconciliation of the U.S. federal statutory income tax rate to the effective tax for the years ended December 31, 2022, 2021 and 2020 are as follows (in thousands):

	Year Ended December 31,
	2022			2021			2020
At federal statutory income tax rate	$	(25,918	)	$	(17,532	)	$	(9,555	)
State income taxes		(2,659	)		(105	)		(3,098	)
Stock-based compensation		2,368			(4,031	)		(5	)
Research & Development credits		(1,779	)		(2,131	)		(512	)
Change in valuation allowance		9,067			11,476			5,710
Other		36			172			321
Foreign rate differential		18,949			11,032			7,380
Prior period true ups		—			1,098			—
Provision (benefit) for income taxes	$	64		$	(21	)	$	241

Schedule of Components of Deferred Tax Assets

Significant components of the Company’s deferred tax assets as of December 31, 2022 and 2021 are as follows (in thousands):

	December 31,
	2022			2021
Deferred tax assets:
Loss carryforwards	$	16,319		$	15,407
Research & other credits		8,435			5,325
Other		14			16
Accrued expenses		1,860			529
Stock options		3,860			1,530
Lease Liabilities		1,323			542
Capitalized R&D		1,702			—
Total deferred tax assets		33,513			23,349
Deferred tax liabilities:
Fixed assets		215			73
Lease ROU assets		1,244			541
Prepaid expenses		252			—
Total deferred tax liabilities		1,711			614
Valuation allowance		(31,802	)		(22,735	)
Net deferred tax assets	$	—		$	—

Summary of Net Operating Loss and Tax Credit Carryforwards

Net operating losses and tax credit carryforwards as of December 31, 2022 are as follows (in thousands):

	Amount		Expiration Years
Net operating losses, federal (Post December 31, 2017)	$	46,835	Do Not Expire
Net operating losses, state	$	68,993	2038-2040
Tax credits, federal	$	5,978	2039-2042
Tax credits, state	$	4,177	N/A
Net operating losses, foreign	$	4,554	N/A

Schedule of Unrecognized Tax Benefits

The Company has the following activity relating to unrecognized tax benefits (in thousands):

	Year Ended December 31,
	2022			2021			2020
Balance at beginning of year	$	1,217		$	842		$	692
Additions/reversals based on tax positions of prior years		13			(69	)		(64	)
Additions based on tax positions related to the current year		443			494			240
Lapses in statutes of limitations		(12	)		(50	)		(26	)
Balance at end of year	$	1,661		$	1,217		$	842