X0306 4 2022-01-21 0 0001253689 GLYCOMIMETICS INC GLYC 0001809747 Semerjian Harout C/O GLYCOMIMETICS, INC 9708 MEDICAL CENTER DRIVE ROCKVILLE MD 20850 1 1 0 0 Chief Executive Officer Employee Stock Option (right to buy) 1.11 2022-01-21 4 A 0 423500 0.00 A 2032-01-20 Common Stock 423500 423500 D 25% of the shares underlying this option will vest on January 21, 2023 and the remaining underlying shares will vest in equal monthly installments over 36 months thereafter, subject to the Reporting Person's continued service with the Issuer through each such vesting date. /s/ Brian F. Leaf, attorney-in-fact 2022-01-25