EX-99.2 3 dp202519_ex9902.htm EXHIBIT 99.2

Exhibit 99.2

 

 

© Immatics. Not for further reproduction or distribution. Delivering the Power of T cells to Cancer Patients © Immatics. Not for further reproduction or distribution. ACTengine® IMA203 / IMA203CD8 TCR - T Monotherapy Targeting PRAME – Phase 1 Interim Data Update Martin Wermke , Professor at the University Hospital Dresden and Coordinating Investigator of the ACTengine ® IMA203 TCR - T trial Cedrik Britten , Chief Medical Officer, Immatics Harpreet Singh , Chief Executive Officer, Immatics November 8, 2023 Additional oral presentation by Martin Wermke at the Society for Melanoma Research Congress on November 08 , 2023 Data cut - off Sep 30, 2023

 

 

 

Forward - Looking Statement This presentation (“Presentation”) is provided by Immatics N . V . (“Immatics” or the “Company”) for informational purposes only . The information contained herein does not purport to be all - inclusive and none of Immatics, any of its affiliates, any of its or their respective control persons, officers, directors, employees or representatives makes any representation or warranty, express or implied, as to the accuracy, completeness or reliability of the information contained in this Presentation . Forward - Looking Statements . Certain statements in this presentation may be considered forward - looking statements . Forward - looking statements generally relate to future events or the Company’s future financial or operating performance . For example, statements concerning timing of data read - outs for product candidates, the timing and outcome of clinical trials, the nature of clinical trials (including whether such clinical trials will be registration - enabling), the timing of IND or CTA filing for pre - clinical stage product candidates, estimated market opportunities of product candidates, the Company’s focus on partnerships to advance its strategy, and other metrics are forward - looking statements . In some cases, you can identify forward - looking statements by terminology such as “may”, “should”, “expect”, “plan”, “target”, “intend”, “will”, “estimate”, “anticipate”, “believe”, “predict”, “potential” or “continue”, or the negatives of these terms or variations of them or similar terminology . Such forward - looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward looking statements . These forward - looking statements are based upon estimates and assumptions that, while considered reasonable, Immatics and its management, are inherently uncertain . New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties . Factors that may cause actual results to differ materially from current expectations include, but are not limited to, various factors beyond management's control including general economic conditions and other risks, uncertainties and factors set forth in the Company’s Annual report on Form 20 - F and other filings with the Securities and Exchange Commission (SEC) . Nothing in this presentation should be regarded as a representation by any person that the forward - looking statements set forth herein will be achieved or that any of the contemplated results of such forward - looking statements will be achieved . You should not place undue reliance on forward - looking statements, which speak only as of the date they are made . The Company undertakes no duty to update these forward - looking statements . No Offer or Solicitation . This communication is for informational purposes only and does not constitute, or form a part of, an offer to sell or the solicitation of an offer to sell or an offer to buy or the solicitation of an offer to buy any securities, and there shall be no sale of securities, in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction . No offer of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933 , as amended, or in an offering exempt from registration . Certain information contained in this Presentation relates to or is based on studies, publications, surveys and the Company’s own internal estimates and research . In addition, all of the market data included in this presentation involves a number of assumptions and limitations, and there can be no guarantee as to the accuracy or reliability of such assumptions . Finally, while the Company believes its internal research is reliable, such research has not been verified by any independent source . All the scientific and clinical data presented within this presentation are – by definition prior to completion of the clinical trial and a clinical study report – preliminary in nature and subject to further quality checks including customary source data verification . 2

 

 

 

Realizing the Full Multi - Cancer Opportunity of PRAME ACTengine® IMA203 (TCR Cell Therapy) and TCER® IMA402 (TCR Bispecific) 3 ACTengine® IMA203 (TCR Cell Therapy) 1 PRAME target prevalence is based on TCGA (for SCLC: in - house) RNAseq data combined with a proprietary mass spec - guided RNA expre ssion threshold; 2 Uveal melanoma target prevalence is based on IMADetect® qPCR testing of screening biopsies from clinical trial patients (n=33); NSCLC: Non - small cell lung cancer, TNBC: Triple - negative breast cancer, HNSCC: Head and neck squamous cell carcinoma; HCC: Hepatocellular carcinoma Phase 1b dose expansion ongoing Dose escalation of Phase 1/2 trial ongoing TCER® IMA402 (TCR Bispecific) Focus today Indication % PRAME positive patients 1 Uterine Carcinoma Uterine Carcinosarcoma Sarcoma Subtypes Cut. Melanoma Uveal Melanoma 2 Ovarian Carcinoma Squamous NSCLC TNBC Small Cell Lung Cancer Kidney Carcinoma Cholangiocarcinoma HNSCC Esophageal Carcinoma Breast Carcinoma Adeno NSCLC HCC Bladder Carcinoma 97% 100% up to 100% ≥ 95% ≥ 91% 84% 68% 63% 45% up to 40% 33% 27% 27% 26% 25% 18% 18% Focus today

 

 

 

ACTengine® IMA203 / IMA203CD8 TCR - T Monotherapy Two Assets with Distinct Opportunities and Near - Term Catalysts 4 GEN1: IMA203 in Melanoma at RP2D GEN2: IMA203CD8 in Solid Tumors Initial Clinical Data • Complete dose escalation • Signal finding in non - melanoma indications, such as ovarian cancer, uterine cancer, NSCLC, triple - negative breast cancer and others Development Path Clinical Data Cell Product Manufacturing • 7 - day manufacturing process, plus 7 - day release testing • RP2D defined at 1 - 10x10 9 total TCR - T cells • Manufacturing success rate: >95% • Well tolerated • 50% (6/12) confirmed objective response rate ( cORR ) • Durability with ongoing responses at 15+ months; mDOR not reached at mFU of 14.4 months • Manageable tolerability • 56% (5/9) confirmed objective response rate ( cORR ) • Durable response at 12+ months; mDOR not reached at mFU of 4.8 months • 6 out of 7 responses ongoing at data cut - off • Enhanced pharmacology with differentiated response pattern Development Path • FDA RMAT designation for multiple PRAME+ cancers including cutaneous & uveal melanoma • IMA203 GEN1 in melanoma targeted to enter registration - enabling Phase 2 trial in 2024 • Update on clinical development plan in 1Q 2024 mDOR : median Duration of Response; mFU : median Follow - up ; RP2D: Recommended Phase 2 Dose Data cut - off Sep 30, 2023

 

 

 

ACTengine® IMA203 / IMA203CD8 TCR - T Trial in Advanced Solid Tumors Overview D ose Level 1 - 4 ( total N=27): Patients in DL4 (N=7) treated at RP2D Phase 1b Dose Expansion Phase 1a Dose Escalation Efficacy population shown: patients treated with IMA203 (Cohort A) or IMA203CD8 (Cohort C) and with at least one available tu mor response assessment post infusion; RP2D: Recommended Phase 2 Dose of 1 - 10x10 9 total TCR - T cells; IMA203 DL4: 0.2 - 1.2x10 9 TCR - T cells/m 2 BSA, IMA203 DL5: 1.201 x 4.7x10 9 TCR - T cells/m 2 BSA; IMA203CD8 DL3: 0.2 - 0.48x10 9 TCR - T cells/m 2 BSA, IMA203CD8 DL4a: 0.481 - 0.8x10 9 TCR - T cells/m 2 BSA, IMA203CD8 DL4b: 0.801 - 1.2x10 9 TCR - T cells/m 2 Data cut - off Sep 30, 2023 Phase 1a and Cohort A data set in appendix; Cohort B deprioritized, detailed analysis in appendix GEN1 : IMA203 GEN2 : IMA203CD8 Functional CD8 TCR - T cells only Functional CD8 and CD4 TCR - T cells Today’s update focuses on 13 melanoma patients treated at RP2D with IMA203 GEN1 and 12 all comers patients treated with IMA203CD8 GEN2 Melanoma Patients at RP2D: Total N=13 (5 Ph1a + 8 Cohort A) Cohort C (N=12): Dose Level 3/4a/4b Dose escalation ongoing Cohort A (total N=18) : Dose Level 4/5 All patients treated at RP2D 5

 

 

 

Overview of Patient Characteristics and Responses 6 * Patients with at least one available tumor response assessment post infusion; # All patients were PD at data cut - off; Initial ORR: Objective response rate according to RECIST 1.1 at any post infusion scan; Confirmed ORR ( cORR ): Confirmed objective response rate according to RECIST 1.1 for patients with at least two available post infusion scans or patients with progressive disease (PD ) a t any prior timepoint, patients with ongoing unconfirmed PR not included in cORR calculation; Duration of response (DOR) in confirmed responders is defined as time from first documented response until disease progression/death. Patients with ongoing response wil l be censored at date of data cut - off. Median DOR is analyzed by using the Kaplan - Meier method; Median Follow - up is analyzed by using the reverse Kaplan - Meier method; DOR: Duration of Response; FU: Follow - up IMA203 GEN1 IMA203CD8 GEN2 All Comers (N=45) Melanoma Subgroup (N=13 of 45) All Comers (N=12) Phase 1a Cohort A Phase 1a + Cohort A Cohort C Efficacy population* N=27 Thereof N=7 at RP2D N=18 at RP2D N=13 at RP2D N=12 Prior lines of systemic treatment ( median, min, max) 4 (1, 8) 3 (0, 10) 4 (0, 7) 3 (1, 5) LDH at baseline >1 x ULN [% of patients] 66.7 50.0 53.8 50.0 Baseline tumor burden Median target lesion sum of diameter [mm] (min, max) 133.0 (29, 219.7) 58.9 (21, 207.3) 52.0 (21.0, 178.7) 79.8 (20.0, 182.0) Dose level DL1 - 4 DL4/5 DL4/5 DL3/DL4a/DL4b ORR 48% (13/27) 50% (9/18) 62% (8/13) 58% (7/12) cORR 19% (5/27) 47% (8/17) 50% (6/12) 56% (5/9) mDOR [months] 4.4 (2.4, 23.0) Not reached Not reached Not reached mFU [months] Not defined # 10.8 14.4 4.8 Data cut - off Sep 30, 2023 Heavily Pretreated Patient Population across Clinical Trial Cohorts

 

 

 

ACTengine® IMA203 TCR - T Interim Update Delivering a Meaningful Benefit to Patients with an Unmet Medical Need 7 IMA203 GEN1 Monotherapy Phase 1a & Cohort A – Focus on Melanoma at RP2D IMA203CD8 GEN2 Monotherapy Cohort C – First Data Set on 2 nd Generation Summary & Next Development Steps

 

 

 

8 Data cut - off Sep 30, 2023 IMA203 GEN1 in All Melanoma Patients at RP2D – Most Frequent Adverse Events • Expected cytopenia (Grade 1 - 4) associated with lymphodepletion in all patients • Mostly mild to moderate cytokine release syndrome (CRS) • 63% (10/16) with Grade 1 CRS • 31% (5/16) with Grade 2 CRS • 6% (1/16) with Grade 3 CRS (Phase 1a patient; recovered to Grade 2 after 3 days, no need for vasopressors and/or ventilation) • No dose - dependent increase of CRS • O ne non - serious, mild (Grade 1) ICANS 2 in DL5 • No dose - limiting toxicity • No IMA203 - related deaths • For full IMA203 GEN1 monotherapy safety profile (generally consistent with safety in melanoma subset), see appendix 1 Three cutaneous melanoma patients treated with IMA203 and pending post infusion scan included in safety population, but not e ff icacy population; 2 I CANS: Immune Effector Cell - Associated N eurotoxicity S yndrome ; CRS and ICANS graded by CARTOX criteria ( Neelapu et al ., 2018) N=16 Patients in Safety Population 1 IMA203 GEN1 monotherapy continues to be well tolerated at total doses between 1 - 10x10 9 TCR - T cells (RP2D)

 

 

 

# # # # # # # # # # IMA203 GEN1 in All Melanoma Patients at RP2D (N=13) – BOR and Response over Time Durable Responses 15+ Months after Treatment 9 Data cut - off Sep 30, 2023 Ongoing ORR 62% (8/13) cORR 50% (6/12) Initial ORR: Objective response rate according to RECIST 1.1 at any post infusion scan; Confirmed ORR ( cORR ): Confirmed objective response rate according to RECIST 1.1 for patients with at least two available post infusion scans or pat ients with progressive disease (PD) at any prior timepoint, patients with ongoing unconfirmed PR not included in cORR calculation; Duration of response (DOR) in confirmed responders is defined as time from first documented response until disease progression/death. Patients with ongoing response will be censored at date of data cut - off. Median DOR is analyzed by using the Kaplan - Meier method; Median Follow - up is analyzed by using the reverse Kaplan - Meier method; PD: Progressive Disease; SD: Stable Disease; PR: Partial Response; cPR : Confirmed Partial Response; BL: Baseline; BOR: Best Overall Response; DOR: Duration of Response; Scans at approximately week 6, month 3 and then every 3 months # Patients in Phase 1a Median DOR, min, max DOR Not reached, 2.2+, 14.7+ months Median Follow - up 14.4 months

 

 

 

10 High Medical Need in Cutaneous and Uveal Melanoma Clinically and Commercially Attractive Features of IMA203 Cutaneous Melanoma Uveal Melanoma Patient Population 2L+ CPI - refractory, BRAF/MEK inhibitor - refractory if BRAF mutation+ 2L+ Kimmtrak - refractory, CPI/chemotherapy - refractory IMA203 Opportunity ~3,000 HLA - A*02:01 and PRAME - positive cutaneous melanoma patients annually in the US 1 ~300 HLA - A*02:01 and PRAME - positive uveal melanoma patients annually in the US 2 Well tolerated Mostly mild to moderate CRS, infrequent & mild ICANS Promising anti - tumor activity ( cORR , mDOR ) Leukapharesis as source for cell product, no surgery required Short manufacturing time of 7 days plus 7 days of QC release testing Low dose IL - 2 post IMA203 infusion with better tolerability profile than high dose IL - 2 CPI: Checkpoint inhibitor; 1 Based on annual mortality of ~7,700 cutaneous melanoma patients in the US, HLA - A*02:01 prevalence of 41% in the US and PRAME pr evalence of 95% (TCGA RNAseq data combined with proprietary MS - guided RNA expression threshold); 2 Based on annual mortality of ~800 uveal melanoma patients in the US, HLA - A*02:01 prevalence of 41% in the US and PRAME prevalen ce of 91% (IMADetect® qPCR testing of screening biopsies from clinical trial patients (n=33)) ≥95% of cutaneous melanoma patients are PRAME - positive Data cut - off Sep 30, 2023 IMA203 GEN1 in Melanoma Targeted to Enter Registration - Enabling Phase 2 Trial in 2024

 

 

 

ACTengine® IMA203 TCR - T Interim Update Delivering a Meaningful Benefit to Patients with an Unmet Medical Need 11 IMA203 GEN1 Monotherapy Phase 1a & Cohort A – Focus on Melanoma at RP2D IMA203CD8 GEN2 Monotherapy Cohort C – First Data Set on 2 nd Generation Summary & Next Development Steps

 

 

 

IMA203CD8 GEN2 – IMA203 TCR - T Monotherapy Leveraging CD8 and CD4 cells Differentiated Pharmacology Compared to 1 st - Generation TCR - only Approaches • IMA203CD8 GEN2 designed to broaden the clinical potential of IMA203 TCR - T monotherapy by adding functional CD4 T cells via co - transduction of CD8 αβ alongside PRAME TCR • Activated CD4 T cells aid activity of other immune cells by releasing cytokines and acquire cytotoxic functions • Functional CD4 T cells mediate longer anti - tumor activity than CD8 T cells and potentiate the anti - tumor activity of the cell product in preclinical studies 1 • Data from CD19 CAR - T - treated leukaemia patients suggest a relevant role of engineered CD4 T cells in long - term durability 2 TUMOR CELL DEATH CD4 T CELL Cytotoxic Activity CD8 T CELL T cell Help Cytotoxic Activity 12 1 Internal data not shown here, published in Bajwa et al. 2021, Journal for Immunotherapy of Cancer; 2 M elenhorst et al. 2022 Nature , Bai et al. 202,2 Science Advances CD8 PRAME TCR

 

 

 

IMA203CD8 GEN2 in Cohort C (N=12) – Most Frequent Adverse Events Manageable Tolerability in 12 Patients Treated with IMA203CD8 at 3 Escalating Dose Levels 1 • Expected cytopenia (Grade 1 - 4) associated with lymphodepletion in all patients • Cytokine release syndrome (CRS) in 92% (11/12) of patients: Trend towards more severe CRS at higher doses, in all cases well manageable • 67 % (8/12) with Grade 1 or 2 CRS (4 in DL3, 3 in DL4a, 1 in DL4b) • 17% (2/12) with Grade 3 CRS (2 in DL4b; patient C - DL4b - 04, see also description below) • 8% (1/12) with Grade 4 CRS (1 in DL4b, patient C - DL4b - 01, see also description below ) • One patient with neurotoxicity (see below), no ICANS 2 or neurotoxicity reported for the other patients • Dose - limiting toxicities (DLTs) at Dose Level 4b were observed in 2 of 4 patients 1) In patient C - DL4b - 01 treated with highest possible dose at DL4b, high biological activity ( in vivo T cell expansion) observed; patient developed Grade 4 neurotoxicity and Grade 4 CRS on day 6 after infusion, combined with Grade 3 Hemophagocytic Lymphohistiocytosis (HLH) 2) Patient C - DL4b - 04 treated at DL4b developed Grade 3 CRS with transient Grade 3 liver enzyme (ALT) increase that resolved to Grad e 2 within 10 days; no need for vasopressors or ventilation at any time • No high - grade CRS, no neurotoxicity and no DLTs were reported for 4 patients treated at DL3 and 4 patients treated at DL4a • No IMA203CD8 - related deaths • Expanded DL4a dose cohort ongoing 13 1 N=4 DL3, N=4 DL4a, N=4 DL4b, DL3: 0.2 - 0.48x10 9 TCR - T cells/m 2 BSA, DL4 is split into a DL4a (0.481 - 0.8x10 9 TCR - T cells/m 2 BSA) and DL4b (0.801 - 1.2x10 9 TCR - T cells/m 2 BSA); 2 I CANS: Immune Effector Cell - Associated N eurotoxicity S yndrome ; CRS and ICANS graded by CARTOX criteria ( Neelapu et al ., 2018) IMA203CD8 GEN2 monotherapy shows a manageable tolerability profile Data cut - off Sep 30, 2023

 

 

 

IMA203CD8 GEN2 in Cohort C (N=12 # ) – BOR and Response over Time Deepening of Response from SD to PR in 2 Patients, 6 Responses Ongoing 14 • 6 out of 7 responses ongoing • 11/12 patients show tumor shrinkage • Deepening of response from SD to PR in two patients (C - DL4a - 01, C - DL4a - 03) • Ongoing durable response 12+ months after infusion Median DOR, min, max DOR Not reached, 2.0+, 11.5+ months Median Follow - up 4.8 months ORR 58% (7/12) cORR 56% (5/9) Initial ORR: Objective response rate according to RECIST 1.1 at any post infusion scan; Confirmed ORR ( cORR ): Confirmed objective response rate according to RECIST 1.1 for patients with at least two available post infusion scans or pat ients with progressive disease (PD) at any prior timepoint, patients with ongoing unconfirmed PR not included in cORR calculation; Duration of response (DOR) in confirmed responders is defined as time from first documented response until disease progressio n/d eath. Patients with ongoing response will be censored at date of data cut - off. Median DOR is analyzed by using the Kaplan - Meier method; Median Follow - up is analyzed by using the reverse Kaplan - Meier method; PD: Progressive Disease; SD: Stable Disease; PR: Partial Response; cPR : Confirmed Partial Response; BL: Baseline; BOR: Best Overall Response; DOR: Duration of Response # Patient C - DL4a - 04 was PD ~6 weeks after infusion, not shown due to non - evaluable target lesions at tumor assessment Scans at approximately week 6, month 3 and then every 3 months Ongoing Data cut - off Sep 30, 2023 * Clinical tumor progress after 4.9 months post infusion, investigator information *

 

 

 

IMA203CD8 GEN2: Translational Data Shows Enhanced Pharmacology Cohort A IMA203 GEN1 (All Patients at RP2D) vs Cohort C IMA203CD8 GEN2 15 Trend towards responses at lower cell dose and higher tumor burden with IMA203CD8 Higher peak expansion ( C max ) of IMA203CD8 T cells when normalized to infused dose Higher activation levels in IMA203CD8 T cells at week 1… …without exhaustion over time Initial translational data indicates higher biological and clinical activity of IMA203CD8 GEN2 % PD - 1 of specific T cells at week1: for patient A - DL5 - 05 data not available for week 1 0 5×10 5 1×10 6 1.5×10 6 2×10 6 2.5×10 6 V e c t o r c o p i e s / μ g g D N A p=0.0010 PR cPR PD/SD Cohort A IMA203 GEN1 Cohort C IMA203CD8 GEN2 Data cut - off Sep 30, 2023

 

 

 

ACTengine® IMA203 TCR - T Interim Update Delivering a Meaningful Benefit to Patients with an Unmet Medical Need 16 IMA203 GEN1 Monotherapy Phase 1a & Cohort A – Focus on Melanoma at RP2D IMA203CD8 GEN2 Monotherapy Cohort C – First Data Set on 2 nd Generation Summary & Next Development Steps

 

 

 

ACTengine® IMA203 / IMA203CD8 TCR - T Monotherapy Targeting PRAME Summary of GEN1 and GEN2 Clinical Data and Planned Next Steps 17 Next Step Alignment with FDA on patient population, trial design, CMC targeting registration - enabling Phase 2 trial in melanoma • Well tolerated, mostly mild to moderate CRS, infrequent & mild ICANS • 50% (6/12) cORR , mDOR not reached at mFU of 14.4 months • Durability with ongoing responses at 15+ months in some patients • RP2D defined at 1 - 10x10 9 total TCR - T cells • FDA RMAT designation received in multiple PRAME expressing cancers including cutaneous and uveal melanoma • Enhanced primary and secondary pharmacology when compared to GEN1 • Manageable tolerability (2 DLTs at DL4b, dose escalation ongoing) • Initial clinical activity observed with differentiated response pattern • 56% (5/9) cORR • 6 out of 7 responses ongoing at data cut - off, durable response at 12+ months • SD converting to PR over time (N=2) • Enhanced biological efficacy with PRs at lower T cell:tumor cell ratio compared to IMA203 GEN1 IMA203 GEN1 Monotherapy in Melanoma at RP2D IMA203CD8 GEN2 Monotherapy IMA203 GEN1 Monotherapy in Melanoma at RP2D Next Step Complete dose escalation and further dose expansion with focus on non - melanoma patients Data cut - off Sep 30, 2023

 

 

 

PRAME mRNA expression in IMA203 GEN1 Phase 1a and Cohort A responders at RP2D (n=13) PRAME mRNA expression in IMA203CD8 GEN2 Cohort C responders (n=7) Potential of IMA203 in Additional Solid Cancer Indications Based on PRAME Expression in IMA203 GEN1 and IMA203CD8 GEN2 Responders 18 % PRAME - positive patients 1 PRAME target expression distribution (blue histogram) based on TCGA RNAseq data, patient data (black dots) based on IMADetect ® q PCR testing of screening biopsies; 1 PRAME target prevalence is based on TCGA RNAseq data combined with a proprietary MS - guided RNA expression threshold; 2 PRAME target prevalence in uveal melanoma based on IMADetect® qPCR testing of screening biopsies from clinical trial patients ( n=33) demonstrates substantial higher prevalence of 91% compared to prevalence based on TCGA data of 50%, TCGA: early & late - stage primary tumor samples, Immatics clinical trials: late - stage/metastatic tumor samples, Role of PRAME in metastasis of uveal melanoma: Field et al. 2016 Clinical Cancer Research; MS: mass spectrometry Data cut - off Sep 30, 2023 ≥ 95% ≥ 91% (50% 2 ) 97% 100% 84% 68% 63% 27% Immatics’ current MS - guided mRNA threshold for patient selection Selected indications Clinical activity shown No clinical activity expected Potential opportunity to see clinical activity

 

 

 

ACTengine® IMA203 / IMA203CD8 TCR - T Monotherapy Targeting PRAME Leveraging the Full Breath of PRAME in Three Steps 19 Development Strategy Step 1 IMA203 GEN1 in cutaneous melanoma (potentially bundled with uveal melanoma) as first tumor type targeted to enter registration - enabling trial Signal finding in ovarian cancer and uterine cancer in dedicated dose expansion cohorts, preferentially with IMA203CD8 GEN2 Pursue tumor - agnostic label in PRAME+ solid cancers to leverage full breadth of PRAME - including NSCLC, triple - negative breast cancer and others Step 2 Step 3 2024 2024

 

 

 

Upcoming 2024 Catalysts for ACTengine® and TCER® Clinical Lead Assets Projected Cash Runway Well into 2026 to Reach Multiple Value Inflections Points 20 IMA203 GEN1 • Update on clinical development plan in 1Q 2024 • Targeted registration - enabling Phase 2 trial for ACTengine® IMA203 GEN1 in melanoma IMA203CD8 GEN2 • Interim data update with longer follow - up planned ACTengine® IMA203 / IMA203CD8 (PRAME) First clinical data update from dose escalation in ongoing Phase 1 trial planned TCER® IMA401 (MAGEA4/8) First clinical data update from dose escalation in ongoing Phase 1/2 trial planned Initial focus indications: Ovarian cancer, uterine cancer, lung cancer, melanoma and others TCER® IMA402 (PRAME) Updates planned across the entire clinical portfolio throughout 2024

 

 

 

University Hospital Dresden University Hospital Bonn University Hospital Würzburg Columbia University University of Pittsburgh MD Anderson Cancer Center University Hospital Hamburg Dr. D . Araujo Dr. A . Tsimberidou Dr. A. Jazaeri Dr. S . Patel Dr. W. Alsdorf Dr. T . Holderried Dr. M . C hatterjee Dr. J . Luke Germany United States Dr. M . Wermke … and the Investigators at the Clinical Sites Dr. R . Reshef 21 We are Immensely Grateful to the Patients, Their Families … Dr. L. Hernandez - Aya University of Miami Health System

 

 

 

Delivering s the Power of T cells to Cancer Patients © Immatics. Not for further reproduction or distribution. www.immatics.com Q&A

 

 

 

Appendix – Additional Data 1. Patient Flow and PRAME Expression in Pre - Treatment Tumor Biopsies 2. Dose Escalation and Cohort A IMA203 GEN1 3. Cohort B IMA203 GEN1 + Nivolumab 4. Cohort C IMA203 GEN2 5. Manufacturing and in vivo Engraftment Data IMA203 GEN1 and IMA203CD8 GEN2

 

 

 

ACTengine® IMA203/IMA203CD8 TCR - T Monotherapy – Patient Flow 24 HLA - A*02 Testing Blood sample; Central lab Treatment & Observation Phase Long Term Follow - up Screening & Manufacturing Phase Manufacturing by Immatics Infusion of ACTengine® IMA203 TCR - T Product Lymphodepletion * Target Profiling IMADetect® Biopsy or archived tissue Low dose IL - 2 ** Safety and efficacy monitoring for 12 months Leukapheresis x x Expression Antigen 1 3 2 Short process time of 14 days * 30 mg/m 2 Flu darabine and 500 mg/m 2 Cy clophosphamide for 4 days; ** 1m IU daily days 1 - 5 and twice daily days 6 - 10 7 - day manufacturing process applying CD8/CD4 T cell selection 7 - day QC release testing Cut. Melanoma Uveal Melanoma Uterine Carcinoma Ovarian Carcinoma 95% (58/61) 91% (30/33) 89% (8/9) 82% (23/28) Patient screening data from Immatics’ clinical trials:

 

 

 

PRAME Expression in Pre - Treatment Tumor Biopsies Comparable PRAME Expression Levels in Patients Treated in Phase 1a Dose Escalation, Cohort A and C 25 Data cut - off Sep 30, 2023 PRAME RNA expression in pre - treatment biopsies relative to threshold Immatics’ mass spectrometry - guided mRNA threshold

 

 

 

PRAME Expression in Pre - Treatment Tumor Biopsies Responders in Cohort A IMA203 GEN1 and Cohort C IMA203CD8 GEN2 26 Indication No significant difference in PRAME expression between Cohort A and C responders Best Overall Response PRAME RNA expression in pre - treatment biopsies relative to threshold Immatics’ mass spectrometry - guided mRNA threshold A - DL5 - 01 A - DL4 - 02 A - DL5 - 03 A - DL5 - 06 A - DL4 - 03 A - DL5 - 07 A - DL4 - 01 A - DL5 - 05 A - DL5 - 10 C - DL3 - 04 C - DL4a - 02 C - DL4b - 04 C - DL4a - 01 C - DL4a - 03 C - DL4b - 02 A - DL3 - 02 Immatics ’ mass spectrometry - guided mRNA threshold A - DL5 - 01 A - DL4 - 02 A - DL5 - 03 A - DL5 - 06 A - DL4 - 03 A - DL5 - 07 A - DL4 - 01 A - DL5 - 05 A - DL5 - 10 C - DL3 - 04 C - DL4a - 02 C - DL4b - 04 C - DL4a - 01 C - DL4a - 03 C - DL4b - 02 A - DL3 - 02 IMA203 achieved objective responses at all expression levels above threshold Mann - Whitney U test Data cut - off Sep 30, 2023

 

 

 

Appendix – Additional Data 1. Patient Flow and PRAME Expression in Pre - Treatment Tumor Biopsies 2. Dose Escalation and Cohort A IMA203 GEN1 3. Cohort B IMA203 GEN1 + Nivolumab 4. Cohort C IMA203 GEN2 5. Manufacturing and in vivo Engraftment Data IMA203 GEN1 and IMA203CD8 GEN2

 

 

 

 

IMA203 GEN1 – Melanoma as First Indication for Pivotal Development 28 * Patients with at least one post treatment tumor response assessment Patient characteristics All comers Cohort A Melanoma pts Ph1a & Cohort A at RP2D Ovarian cancer pts Ph1a & Cohort A at RP2D Efficacy population* 18 13 4 Prior lines of treatment Median (min, max) 3 (0, 10) 4 (0, 7) 4.5 (3, 10) LDH at baseline >1 x ULN [% of patients] 50.0 53.9 100.0 Baseline tumor burden Target lesion sum of diameter [mm] (median, min, max) 58.9 (21.0, 207.3) 52.0 (21.0, 178.7) 108.8 (50.6, 207.3) Patient Numbers* ALL Melanoma Ovarian Cancer Synovial Sarcoma H&N Cancer Others Phase 1a RP2D 7 5 0 0 0 2 Cohort A RP2D 18 8 4 3 1 2 All 8 cut. melanoma patients were CPI - refractory and 5 of 8 were BRAF - inhibitor pretreated • Sub - group analysis per tumor type at target dose includes data from Phase 1a plus Cohort A at RP2D • Melanoma patient number (N=13) and characteristics allow such sub - group analysis for initial assessment of anti - tumor activity • For other tumor types, appropriate patient numbers and characteristics have not yet been achieved All ovarian cancer patients were platinum - resistant IMA203 GEN1 Data cut - off Sep 30, 2023

 

 

 

IMA203 GEN1 in Phase 1a Dose Escalation (N=27 # ) – BOR and Response over Time 29 * Maximum change of target lesions and RECIST 1.1 BOR at different timepoints ; # Synovial sarcoma patient (DL3) PD at week 6 not shown as t arget lesions were not evaluable; PD: Progressive disease; SD: Stable disease; PR: Partial response; cPR : Confirmed partial response; BL: Baseline Best overall response (RECIST1.1) IMA203 GEN1 Data cut - off Sep 30, 2023

 

 

 

* IMA203 GEN1 in Cohort A (N=18) – BOR and Response over Time Objective Responses across Multiple Solid Cancer T ypes 30 1 Patient received one dose nivolumab erroneously; 2 Progressive disease at month 6 due to unequivocal progression of non - target lesions, target lesions not evaluable due to externa l assessment ; Initial ORR: Objective response rate according to RECIST 1.1 at any post infusion scan; Confirmed ORR ( cORR ): Confirmed objective response rate according to RECIST 1.1 for patients with at least two available post infusion scans or pat ients with progressive disease (PD) at any prior timepoint, patients with ongoing unconfirmed PR not included in cORR calculation; Duration of response (DOR) in confirmed responders is defined as time from first documented response until disease progressio n/d eath. Patients with ongoing response will be censored at date of data cut - off. Median DOR is analyzed by using the Kaplan - Meier method; Median Follow - up is analyzed by using the reverse Kaplan - Meier method; PD: Progressive Disease; SD: Stable Disease; PR: Partial Response; cPR : Confirmed Partial Response; BL: Baseline; BOR: Best Overall Response; DOR: Duration of Response Data cut - off Sep 30, 2023 Median DOR, min, max DOR Not reached, 2.2+, 14.7+ months Median Follow - up 10.8 months Scans at approximately week 6, month 3 and then every 3 months Ongoing ORR 50% (9/18) cORR 47% (8/17) * Response until 5.7 months post infusion, target lesion response assessment not available (external assessment) IMA203 GEN1

 

 

 

31 Data cut - off Sep 30, 2023 IMA203 GEN1 in Cohort A – Most Frequent Adverse Events N=21 Patients in Safety Population 1 • Expected cytopenia (Grade 1 - 4) associated with lymphodepletion in all patients • Mild - moderate cytokine release syndrome (CRS) in 90% (19/21) of patients • 43% (9/21) with Grade 1 CRS • 48% (10/21) with Grade 2 CRS • No dose - dependent increase of CRS • O ne non - serious, mild (Grade 1) ICANS 2 in DL5 • No dose - limiting toxicity • No IMA203 - related deaths 1 Three cutaneous melanoma patients treated with IMA203, and pending post infusion scan included in safety population, but not ef ficacy population; 2 I CANS: Immune Effector Cell - Associated N eurotoxicity S yndrome ; CRS and ICANS graded by CARTOX criteria ( Neelapu et al ., 2018) IMA203 GEN1 monotherapy continues to be well tolerated at total doses between 1 - 10x10 9 TCR - T cells (RP2D) IMA203 GEN1

 

 

 

Adverse event ( System organ class , Preferred term ) ≥ Grade 3 No . % Patients with any adverse event 49 100.0 Adverse Events of Special Interest 2 4.1 Cytokine release syndrome 2 4.1 ICANS 2 0 0.0 Blood and lymphatic system disorders 48 98.0 Neutropenia 36 73.5 Lymphopenia 27 55.1 Leukopenia 26 53.1 Anaemia 24 49.0 Thrombocytopenia 17 34.7 Cytopenia 1 2.0 Leukocytosis 1 2.0 Lymphocytosis 1 2.0 Investigations 9 18.4 Neutrophil count decreased 4 8.2 Alanine aminotransferase increased 2 4.1 Aspartate aminotransferase increased 2 4.1 White blood cell count decreased 2 4.1 Blood alkaline phosphatase increased 1 2.0 Blood creatinine increased 1 2.0 Blood fibrinogen decreased 1 2.0 Infections and infestations 7 14.3 Appendicitis 1 2.0 COVID - 19 1 2.0 Enterococcal infection 1 2.0 Infection 1 2.0 Orchitis 1 2.0 Sepsis 4,5 1 2.0 Septic shock 4 1 2.0 Urinary tract infection 1 2.0 Respiratory, thoracic and mediastinal disorders 6 12.2 Hypoxia 3 6.1 Bronchial obstruction 1 2.0 Laryngeal inflammation 1 2.0 Pleural effusion 1 2.0 Respiratory failure 1 2.0 Vascular disorders 6 12.2 Hypertension 4 8.2 Hypotension 2 4.1 Adverse event ( System organ class , Preferred term ) ≥ Grade 3 No . % table continued… General disorders and administration site conditions 4 8.2 Condition aggravated 4 1 2.0 Fatigue 1 2.0 Pyrexia 1 2.0 Swelling face 1 2.0 Metabolism and nutrition disorders 4 8.2 Hypokalaemia 3 6.1 Failure to thrive 1 2.0 Hypophosphataemia 1 2.0 Gastrointestinal disorders 2 4.1 Abdominal pain 1 2.0 Diarrhoea 1 2.0 Vomiting 1 2.0 Injury, poisoning and procedural complications 2 4.1 Humerus fracture 1 2.0 Infusion related reaction 1 2.0 Renal and urinary disorders 2 4.1 Acute kidney injury 1 2.0 Proteinuria 1 2.0 Skin and subcutaneous tissue disorders 2 4.1 Rash maculo - papular 2 4.1 Cardiac disorders 1 2.0 Atrial fibrillation 3 1 2.0 Endocrine disorders 1 2.0 Inappropriate antidiuretic hormone secretion 1 2.0 Eye disorders 1 2.0 Ulcerative keratitis 1 2.0 Hepatobiliary disorders 1 2.0 Cholangitis 1 2.0 Immune system disorders 1 2.0 Contrast media allergy 1 2.0 Musculoskeletal and connective tissue disorders 1 2.0 Muscle spasms 1 2.0 Nervous system disorders 1 2.0 Headache 1 2.0 Reproductive system and breast disorders 1 2.0 Vaginal haemorrhage 1 2.0 Tolerability Data – IMA203 GEN1 across All Dose Levels Phase 1a Dose Escalation and Cohort A – All ≥Grade 3 Adverse Events (N=49) 32 • Well tolerated at doses as high as ~10x10 9 TCR - T cells • No AE ≥Grade 3 was observed with a frequency ≥10% when excluding expected cytopenia associated with lymphodepletion • No IMA203 - related Grade 5 Adverse Events All treatment - emergent adverse events (TEAEs) with ≥ Grade 3 regardless of relatedness to study treatment that occurred in at least 1 patient (except for ICANS, where only Grade 1 - 2 occurred ; listed for completeness due to being an adverse event of special interest) are presented . Adverse events were coded using the Medical Dictionary for Regulatory Activities . Grades were determined according to National Cancer Institute Common Terminology Criteria of Adverse Events, version 5 . 0 . Grades for CRS and ICANS were determined according to CARTOX criteria ( Neelapu et al . , 2018 ) . Patients are counted only once per adverse event and severity classification . Based on interim data extracted from open clinical database ( 30 - Sep - 2023 ) ; 1 Two patients with disease progression after first IMA 203 infusion received exploratory second IMA 203 infusion . They had these ≥ Grade 3 TEAEs only after second infusion, which are included in the table : First patient : Abdominal pain, Cytokine release syndrome, Diarrhoea , Hypokalaemia , Proteinuria ; Second patient : Humerus fracture, Muscle spasms, Neutropenia, Thrombocytopenia ; 2 ICANS : Immune effector cell - associated neurotoxicity syndrome ; 3 DLT : Dose limiting toxicity in phase 1 a at DL 2 reported on March 17 , 2021 ; 4 Fatal Adverse events were not considered related to any study drug ; 5 Patient died from sepsis of unknown origin and did not receive IMA 203 TCR - T cells . TEAEs by maximum severity for all patients in Phase 1a dose escalation and Cohort A dose expansion (N=49) 1 IMA203 GEN1 Data cut - off Sep 30, 2023

 

 

 

Tolerability Data – IMA203 GEN1 at RP2D Phase 1a DL4 and Cohort A – All ≥Grade 3 Adverse Events (N=28) 33 • IMA203 was well tolerated at doses as high as ~10x10 9 TCR - T cells • Most frequent ≥Grade 3 AEs were expected cytopenia associated with lymphodepletion • No IMA203 - related Grade 5 AEs All treatment - emergent adverse events (TEAEs) with ≥ Grade 3 regardless of relatedness to study treatment that occurred in at least 1 patient (except for ICANS, where only Grade 1 - 2 occurred ; listed for completeness due to being an adverse event of special interest) are presented . Adverse events were coded using the Medical Dictionary for Regulatory Activities . Grades were determined according to National Cancer Institute Common Terminology Criteria of Adverse Events, version 5 . 0 . Grades for CRS and ICANS were determined according to CARTOX criteria ( Neelapu et al . , 2018 ) . Patients are counted only once per adverse event and severity classification . Based on interim data extracted from open clinical database ( 30 - Sep - 2023 ) ; 1 One patient in Phase 1 a DL 4 with disease progression after first IMA 203 infusion received exploratory second IMA 203 infusion and had these ≥ Grade 3 TEAEs only after second infusion, which are included in the table : Humerus fracture, Muscle spasms, Neutropenia, Thrombocytopenia ; 2 ICANS : Immune effector cell - associated neurotoxicity syndrome ; 3 Fatal Adverse events were not considered related to any study drug Adverse event ( System organ class , Preferred term ) ≥ Grade 3 No . % Patients with any adverse event 28 100.0 Adverse Events of Special Interest 1 3.6 Cytokine release syndrome 1 3.6 ICANS 2 0 0.0 Blood and lymphatic system disorders 27 96.4 Neutropenia 18 64.3 Anaemia 14 50.0 Leukopenia 13 46.4 Lymphopenia 11 39.3 Thrombocytopenia 9 32.1 Leukocytosis 1 3.6 Lymphocytosis 1 3.6 Investigations 7 25.0 Neutrophil count decreased 4 14.3 Alanine aminotransferase increased 2 7.1 Aspartate aminotransferase increased 2 7.1 White blood cell count decreased 2 7.1 Blood alkaline phosphatase increased 1 3.6 Infections and infestations 3 10.7 Infection 1 3.6 Septic shock 3 1 3.6 Urinary tract infection 1 3.6 Respiratory, thoracic and mediastinal disorders 3 10.7 Hypoxia 2 7.1 Laryngeal inflammation 1 3.6 Vascular disorders 3 10.7 Hypotension 2 7.1 Hypertension 1 3.6 Metabolism and nutrition disorders 2 7.1 Failure to thrive 1 3.6 Hypokalaemia 1 3.6 Hypophosphataemia 1 3.6 Eye disorders 1 3.6 Ulcerative keratitis 1 3.6 Adverse event ( System organ class , Preferred term ) ≥ Grade 3 No . % table continued… General disorders and administration site conditions 1 3.6 Pyrexia 1 3.6 Hepatobiliary disorders 1 3.6 Cholangitis 1 3.6 Injury, poisoning and procedural complications 1 3.6 Humerus fracture 1 3.6 Musculoskeletal and connective tissue disorders 1 3.6 Muscle spasms 1 3.6 Nervous system disorders 1 3.6 Headache 1 3.6 Skin and subcutaneous tissue disorders 1 3.6 Rash maculo - papular 1 3.6 TEAEs by maximum severity for all patients in Ph1a dose escalation DL4 and Ph1b Cohort A dose expansion ( RP2D, N=28) 1 Data cut - off Sep 30, 2023 IMA203 GEN1

 

 

 

Biological Data Consistent with Clinical Data – IMA203 GEN1 IMA203 T cell Levels and Tumor Infiltration across Patients in Phase 1a and Cohort A 34 Data cut - off Sep 30, 2023 Mann - Whitney U test; 1 T cell infiltration for 22 patients (11 non - responder, 11 responder) with 6 - week post infusion biopsy available (1 patient with ~4 - week, 3 patients with ~13 - week post infusion biopsy); PD: Progressive Disease; SD: Stable Disease; PR: Partial Response; cPR : Confirmed Partial R esponse Persistence over time Peak expansion ( C max ) 2 6 1 0 1 4 1 8 1×10 -1 1×10 0 1×10 1 1×10 2 1×10 3 1×10 4 1×10 5 1×10 6 1×10 7 2 0 6 0 1 0 0 1 4 0 1 8 0 2 0 0 4 0 0 6 0 0 8 0 0 1 0 0 0 Days post infusion V e c t o r c o p i e s / μ g g D N A Phase 1A (n=27) Cohort A (n=18) Tumor Infiltration IMA203 T cells found in all evaluable tumor tissues, level of infiltration associated with objective responses 1 Increased levels of IMA203 T cells in the blood of patients in Cohort A following increase of cell dose and switch to T cell enrichment process Phase 1A Cohort A 0 5×10 5 1×10 6 1.5×10 6 2×10 6 2.5×10 6 V e c t o r c o p i e s / μ g g D N A PR cPR PD/SD (n=27) (n=18) p<0.0001 n=45 IMA203 GEN1

 

 

 

Melanoma Patients – Phase 1a and Cohort A IMA203 GEN1 (N=13) Cohort Patient ID Indication No of prior treatment lines Prior treatments Total infused dose TCR - T cells 1 [x10 9 ] BOR BOR (Max % change of target lesions) Comment Reason for Progression Cohort A A - DL5 - 01 Uveal Melanoma 1 ARRY614 + Nivolumab 4.16 cPR - 69.4 Ongoing response 16.0 months post infusion Cohort A A - DL4 - 03 Cut. Melanoma 7 Dabrafenib + Trametinib Pembrolizumab Dabrafenib + Trametinib Vemurafenib + Cobimetinib Dabrafenib + Trametinib Tebentafusp Encorafenib + Binimetinib 1.30 cPR - 78.3 Ongoing response 15.8 months post infusion Cohort A A - DL5 - 03 Cut. Melanoma 3 Interferon Pembrolizumab Ipilimumab + Nivolumab 5.12 cPR - 65.1 Ongoing response 12.2 months post infusion Cohort A A - DL5 - 10 Uveal Melanoma 1 SEAGEN CD40 Agonist 2.68 cPR - 40.8 Ongoing response 3.4 months post infusion Phase 1a DL4 - 02 Cut. Melanoma 5 Dabrafenib + Trametinib Ipilimumab + Nivolumab Nivolumab Ipilimumab + Nivolumab Vemurafenib + Cobimetinib 1.07 cPR - 51.4 Response until 4.4 months post infusion New lesions, progressing non - target lesions Phase 1a DL4 - 06 Cut. Melanoma 4 Pembrolizumab Pembrolizumab Ipilimumab + Nivolumab Nivolumab 1.21 cPR - 61.4 Response until 3.7 months post infusion New lesions Phase 1a DL4 - 01 Cut. Melanoma 7 Interferon NY - ESO - 1, Tyrosinase, MAGE - A3. TPTE, LIP - Merit - study (experimental therapy) Nivolumab Pembrolizumab Ipilimumab + Nivolumab Decortin + Infiliximab Nivolumab + Ipilimumab + Mekinist + Infiliximab 1.16 PR - 39.0 Unconfirmed response until 2.8 months post infusion New lesions, progressing target lesions Phase 1a DL4 - 03 Cut. Melanoma 7 Vemurafenib + Cobimetinib Nivolumab Dabrafenib + Trametinib Ipilimumab + Nivolumab Encorafenib + Binimetinib Pembrolizumab Encorafenib + Binimetinib 1.72 PR - 51.6 Unconfirmed response until 2.4 months post infusion Progressing target lesions Cohort A A - DL4 - 04 Melanoma (Unk. Primary) 2 Ipilimumab + Nivolumab Nivolumab 1.73 SD 0.0 Disease stabilization until 5.7 months post infusion Non - target lesion progression and a new lesion Cohort A A - DL4 - 05 Cut. Melanoma 5 Nivolumab Nivolumab (re - exposure) Nivolumab + Ipilimumab Dabrafenib + Trametinib Nivolumab 1.63 SD 11.4 Disease stabilization until 5.8 months post infusion New lesions, target lesion progression Cohort A A - DL5 - 12 Uveal Melanoma 3 Tyrosinase peptides Nivolumab + Ipilimumab + Denosumab Tebentafusp 4.50 SD - 22.6 Ongoing disease stabilization 2.2 months post infusion Phase 1a DL4 - 07 Cut. Melanoma 6 Interferon alpha Pembrolizumab Ipilimumab + Nivolumab Nivolumab LXH254 + Ribociclib DKY709 Helios 2.09 PD 0.0 Progressive disease 1.4 months post infusion New lesions, progressing non - target lesions Cohort A A - DL4 - 06 Uveal Melanoma 0 NA 2.56 PD - 6.3 Progressive disease 1.3 months post infusion New target lesion 35 1 Transduced viable CD8 T cells; PD: Progressive Disease; Efficacy population shown ( Patients with at least one available tumor response assessment post infusion) ; SD: Stable Disease; PR: Partial Response; cPR : Confirmed Partial Response; BL: Baseline; BOR: Best Overall Response Data cut - off Sep 30, 2023 IMA203 GEN1

 

 

 

Indications beyond Melanoma – Cohort A IMA203 GEN1 (N=10) 36 Patient ID Indication No of prior treatment lines Prior treatments Total infused dose TCR - T cells 1 [x10 9 ] BOR BOR (Max % change of target lesions) Comment Reason for Progression A - DL4 - 01 Head & Neck Cancer 1 Paclitaxel + Carboplatin 1.92 cPR - 33.3 Response until 5.7 months post infusion Non - target lesion progression A - DL5 - 07 Synovial Sarcoma 2 Melphalan + TNF alpha Doxorubicin + Ifosphamid 6.01 cPR - 44.3 Ongoing response 4.4 months post infusion A - DL5 - 05 Ovarian Cancer 3 Adriamycin + Cytoxan + Taxol Carboplatin + Taxol Carboplatin + Doxil 8.84 cPR - 61.7 Response until 4.4 months post infusion New lesions, target and non - target lesion progression A - DL4 - 02 Ovarian Cancer 10 Carboplatin + Taxol Taxol Gemcitabine + Carboplatin Olaparib Letrozole Rubaparib UPCC 03118 Bevacizumab + Cyclophosphamide Carboplatin Doxorubicin 1.97 cPR - 41.0 Response until 3.8 months post infusion Non - target lesion progression A - DL5 - 06 Synovial Sarcoma 1 Adriamycin + Ifosfamide + Trabectedin 3.94 PR - 74.8 Response until 2.8 months post infusion Target and non - target lesion progression A - DL5 - 08 Small Cell Lung Cancer (SCLC) 4 Cisplatin + Etoposid Carboplatin + Etoposid+ Atelizumab Topotecan Paclitaxel 5.09 SD - 1.8 Disease stabilization until 3.0 months post infusion New lesions, target lesion progression A - DL5 - 02 Pancreatic NET 3 Lanreotid Streptozocin + 5 - Fluorouracil Everolismus 5.12 SD - 21.8 Disease stabilization until 2.3 months post infusion Non - target lesion progression A - DL5 - 04* Ovarian Cancer 5 Paclitaxel + Carboplatin Niraparib Doxorubicin + Liposomal + Carboplatin 2020 - 0808 ZN - C3 + Gemcitabine 2020 - 0755 COM 701 + BMS - 986207 + Nivolumab 4.68 PD 50.8 Progressive disease at 1.2 months post infusion New lesions, target - and non - target lesion progression A - DL5 - 09 Ovarian Cancer 4 Paclitaxel + Carboplatin Bevacizumab Doxurubicin + Carboplatin AVB - 001 Cell infusion 6.36 PD - 2.4 Progressive disease at 1.5 months post infusion New target lesion A - DL5 - 11 Synovial Sarcoma 5 Adriamycin + Isofamide Pazobanib NY - ESO1 - TCR T - Cells Pazobanib BRD9 PROTAC CFT8634 9.36 SD - 26.4 Clinical progression 2.0 months post infusion Clinical progression 1 Transduced viable CD8 T cells; PD: Progressive Disease; * Ovarian cancer patient A - DL5 - 04 erroneously received one dose of nivolumab and is part of intent - to - treat population (shown here) but not per - protocol population. SD: Stable Disease; PR: Partial Response; cPR : Confirmed Partial Response; BL: Baseline; BOR: Best Overall Response Data cut - off Sep 30, 2023 IMA203 GEN1

 

 

 

Appendix – Additional Data 1. Patient Flow and PRAME Expression in Pre - Treatment Tumor Biopsies 2. Dose Escalation and Cohort A IMA203 GEN1 3. Cohort B IMA203 GEN1 + Nivolumab 4. Cohort C IMA203 GEN2 5. Manufacturing and in vivo Engraftment Data IMA203 GEN1 and IMA203CD8 GEN2

 

 

 

 

Cohort B: ACTengine® IMA203 TCR - T + Nivolumab Summary • IMA203 TCR - T combined with nivolumab was well tolerated with no unexpected adverse events or additive toxicities • The combination therapy showed clinical activity with one durable objective response exceeding 12 months post infusion and tumor shrinkage in 4 of 6 evaluable patients • No synergistic anti - tumor effects were observed: • Clinical activity in combination cohort was lower compared to IMA203 monotherapy (Cohort A), but comparison is confounded by more unfavorable patient characteristics and lower applied median cell dose in IMA203 + nivolumab combination cohort • Trend towards lower T cell infiltration as well as increased terminal differentiation and signs of exhaustion of IMA203 T cel ls in combination with nivolumab • Data set is too small and heterogenous to draw firm conclusions • Patient case study could indicate potential for clinical benefit of IMA203 TCR - T treatment in combination with checkpoint inhibitors in patients with PD - 1/PD - L1 upregulation » IMA203 in combination with nivolumab deprioritized due to • high monotherapy activity in Cohort A IMA203 and Cohort C IMA203CD8 • lack of synergistic anti - tumor effects 38 Analysis of per - protocol population treated with IMA203 + nivolumab Data cut - off Sep 30, 2023 IMA203 + Nivo

 

 

 

Patient Flow – Cohort B IMA203 + Nivolumab 39 HLA - A*02 Testing Blood sample; Central lab Treatment & Observation Phase Long Term Follow - up Screening & Manufacturing Phase Manufacturing by Immatics Infusion of ACTengine® IMA203 TCR - T Product Lymphodepletion * Target Profiling IMADetect ® Biopsy or archived tissue Low dose IL - 2 ** Safety and efficacy monitoring for 12 months Leukapheresis x x Expression Antigen 1 3 2 Short process time of 14 days * 30 mg/m 2 Flu darabine and 500 mg/m 2 Cy clophosphamide for 4 days; ** 1m IU daily days 1 - 5 and twice daily days 6 - 10; ***Nivolumab at Day 14, or Day 21 post IMA203 infusion. Two weeks after the first infusion of nivolumab and thereafter approximately every 4 weeks, patients receive nivolumab for up to 1 year 7 - day manufacturing process 7 - day QC release testing Nivolumab*** IMA203 + Nivo

 

 

 

PRAME Expression in Pre - Treatment Tumor Biopsies Comparable PRAME Expression Levels in Patients Treated in Cohort A and B 40 Data cut - off Sep 30, 2023 PRAME RNA expression in pre - treatment biopsies relative to threshold Immatics’ mass spectrometry - guided mRNA threshold IMA203 + Nivo Mann - Whitney U test

 

 

 

Patient Characteristics Dose Escalation vs. Cohort A IMA203 vs. Cohort B IMA203 + Nivolumab 41 • Heavily pre - treated, metastatic last - line patients that have exhausted all available SOC treatments • Patients in IMA203+Nivo cohort had more prior lines of treatment and higher tumor burden while receiving lower cell numbers compared to IMA203 monotherapy cohort (i.e. lower E:T ratio in IMA203+Nivo cohort) 1 *Efficacy population in Phase 1a and Cohort A: patients with at least one available tumor response assessment post infusion ; **Efficacy per - protocol population Cohort B: patients received IMA203 + nivolumab and have at least one available tumor response assessment post infusion or reported clinical PD; 1 Demonstrated to be associated with durable response: Locke et al. 2020 Blood Advances Phase 1a Dose Escalation Phase 1b Dose Expansion All pts* Cohort A IMA203 * Cohort B IMA203+Nivo ** Patients treated 27 18 6 Age Median (min, max) 55.0 (18, 72) 52.5 (31, 79) 51.5 (38, 63) Prior lines of treatment Median (min, max) 4.0 (1,8) 3.0 (0, 10) 5.5 (0, 8) LDH at baseline >1 x ULN [% of patients] 66.7 50.0 66.7 Baseline tumor burden Target lesion sum of diameter [mm] Median (min, max) 133.0 (29.0, 219.7) 58.9 (21.0, 207.3) 117.3 (37.0, 280.2) Dose Level DL1 - 4 DL4/5 DL4 Total infused dose ​ Median transduced viable CD8 ​ T cells infused [x10 9 ] (min, max) 0.41 (0.08, 2.09) 4.33 (1.30, 9.36) 2.24 (0.66, 2.71) Data cut - off Sep 30, 2023 IMA203 + Nivo

 

 

 

Most Frequent Adverse Events – Cohort B IMA203 + Nivolumab (N=7) 1 Manageable Treatment - Emergent Adverse Events (TEAEs) • Expected cytopenia (Grade 1 - 4) associated with lymphodepletion in all patients • Low - moderate (Grade 1 - 2) cytokine release syndrome (CRS) in 100% (7/7) of patients • 57% (4/7) of patients had Grade 1 CRS • 43% (3/7) of patients had Grade 2 CRS • Low - grade ICANS 2 in 14% (1/7) of patients ​ • No events indicating immune - mediated adverse reactions in association with nivolumab • No hints that combination with nivolumab increased number or severity of observed TEAEs ​ 42 1 One patient treated with IMA203 + nivolumab withdrew consent 1.1 months post infusion (prior to first scan) and is included s afe ty per - protocol population, but not efficacy per - protocol population; 2 I CANS: Immune Effector Cell - Associated Neurotoxicity Syndrome; CRS and ICANS graded by CARTOX criteria ( Neelapu et al ., 2018) IMA203 TCR - T in combination with nivolumab was well tolerated, no unexpected or additive toxicities compared to IMA203 TCR - T monotherapy Data cut - off Sep 30, 2023 IMA203 + Nivo

 

 

 

Detailed Tolerability Data – Cohort B IMA203 + Nivolumab (N=7) 1 All ≥Grade 3 Adverse Events (N=7) 43 Adverse event ≥ Grade 3 ( System organ class , preferred term) No. % Patients with any adverse event 7 100.0 Adverse events of special interest 0 0.0 Cytokine release syndrome 0 0.0 Immune effector cell - associated neurotoxicity syndrome 0 0.0 Blood and lymphatic system disorders 7 100.0 Neutropenia 7 100.0 Anaemia 6 85.7 Lymphopenia 6 85.7 Thrombocytopenia 3 42.9 Leukopenia 2 28.6 Febrile neutropenia 1 14.3 General disorders and administration site conditions 2 28.6 Pyrexia 2 28.6 Investigations 1 14.8 Aspartate aminotransferase increased 1 14.3 TEAEs by maximum severity for all patients in Cohort B IMA203 + Nivolumab (N=7) All treatment - emergent adverse events (TEAEs) with ≥ Grade 3 regardless of relatedness to study treatment that occurred in at least 1 patient (except for ICANS and CRS, where only lower grades occurred ; listed for completeness due to being adverse events of special interest) are presented . Adverse events were coded using the Medical Dictionary for Regulatory Activities . Grades were determined according to National Cancer Institute Common Terminology Criteria of Adverse Events, version 5 . 0 . Grades for CRS and ICANS were determined according to CARTOX criteria ( Neelapu et al . , 2018 ) . Patients are counted only once per adverse event and severity classification . Based on interim data extracted from open clinical database ( 30 - Sep - 2023 ) • IMA203 TCR - T in combination with nivolumab was well tolerated • No unexpected or additive toxicities compared to IMA203 TCR - T monotherapy • Most frequent ≥Grade 3 AEs were expected cytopenia associated with lymphodepletion • No IMA203 - related Grade 5 AEs 1 One patient treated with IMA203 + nivolumab withdrew consent 1.1 months post infusion (prior to first scan) and is included s afe ty per - protocol population, but not efficacy per - protocol population; Data cut - off Sep 30, 2023 IMA203 + Nivo

 

 

 

Best Overall Response & Durability – Cohort B IMA203 + Nivolumab (N=6) Ongoing Durable Response 12+ Months post Treatment 44 1 Initial ORR: Objective response rate according to RECIST 1.1 at any post infusion scan; 2 Confirmed ORR ( cORR ): Confirmed objective response rate according to RECIST 1.1 for patients with at least two available post infusion scans or patients with progressive disease (PD) at any prior timepoint, patients with ongoing unconfi rme d PR not included in cORR calculation; PD: Progressive Disease; SD: Stable Disease; PR: Partial Response; cPR : Confirmed Partial Response; BL: Baseline; BOR: Best Overall Response; CPI: Checkpoint Inhibitor . * Maximum change of target lesions at time of tumor progression. ORR 1 33% (2/6) cORR 2 17% (1/6) Data cut - off Sep 30, 2023 Pt B - DL 4 - 05 not shown due to clinical progression prior to 1 st post infusion scan, response assessment not available, considered as non - responder for ORR and cORR • Tumor shrinkage in 4 of 6 patients • Ongoing long - term durable response 12+ months post treatment in melanoma patient • All cut. melanoma patients were CPI - refractory • Tumor burden of patient B - DL4 - 04 was among the highest we ever treated with tumor regression in multiple lesions observed (see patient case) • Patient B - DL4 - 07 with significant reduction of target lesions but progression of non - target lesion in the brain, thus PD in BOR analysis Scans at approximately week 6, month 3 and then every 6 months Ongoing IMA203 + Nivo

 

 

 

 

Particularly Hard - to - Treat Patient Population – Cohort B IMA203 + Nivolumab 45 Patient ID Indication No of prior treatment lines Prior treatments Total infused dose TCR - T cells [x10 9 ] BOR BOR (Max % change of target lesions) Comment Reason for Progression B - DL4 - 06 Uveal Melanoma 0 NA 2.22 cPR - 81.2 Ongoing response 12 months post infusion On trial B - DL4 - 04 Melanoma (Unk. Primary) 6 Nivolumab/NKTR - 214, N ivolumab/Ipilimumab, Encorafenib/Binimetinib, CLXH254C12210 (Panrafi+ERKI) Encorafenib/Binimetinib/Pembrolizumab, Carboplatin/Paclitaxel 2.42 PR - 35.6 Unconfirmed response until 2.6 months post infusion Unequivocal progression of non - target lesion in the adrenal gland B - DL4 - 01 Cut. Melanoma 6 Dabrafenib/Trametinib, Nivolumab/Ipilimumab, Nivolumab Encorafenib / Binimetinib Nivolumab/Ipilimumab, Nivolumab 2.17 SD - 13.3* Disease stabilization until 2.7 months post infusion Unequivocal progression of non - target lesion in the lung and new lung lesion B - DL4 - 03 Thymus cancer 2 Carboplatin/Paclitaxel, Doxorubicin/Cisplatin/Cyclophosphamide 0.66 SD 5.5 Disease stabilization until 3.0 months post infusion Target Lesion progression B - DL4 - 07 Cut. Melanoma 5 Pembrolizumab, Dabrafenib/Trametinib, Nivolumab/Ipilimumab, Nivolumab, Encorafinib/Binimetinib 2.71 PD - 48.6* Progressive disease at 1.4 months post infusion Unequivocal progression of non - target lesion in the brain B - DL4 - 05 Rhabdomyosarcoma 8 Adriamycine/Ifosfamide/Vincristine, Ifosfamide/Doxorubicin, Ifosfamide/Doxorubicin, Etoposide/Topotecan/Carboplatin/Cyclophosphamide Trofosfamide/Etoposide/Idarubicine Doxorubicin/Ifosfamide, Carboplatin/Topotecan, Vincristine 2.25 PD NA Clinical progression at 0.9 months post infusion (prior to first scan) Clinical progression (persistent rise in LDH, growing lymph node) B - DL4 - 02 Fibrosarcoma 5 Vincristin / Ifosfamid /Doxorubicin, Epirubicin / Ifosfamid , Gemcitabin /Docetaxel, Pazopanib, Trabectedin 1.07 NA NA Withdrawal of consent 1.1 months post infusion (prior to first scan); safety population NA * Maximum change of target lesions at time of tumor progression. Patient case Data cut - off Sep 30, 2023 IMA203 + Nivo

 

 

 

IMA203 T cell Levels – Molecular Immunomonitoring Cohort A IMA203 vs. Cohort B IMA203 + Nivolumab 46 Statistical test: Mann - Whitney U 2 6 1 0 1 4 1 8 1×10 -1 1×10 0 1×10 1 1×10 2 1×10 3 1×10 4 1×10 5 1×10 6 1×10 7 2 0 4 0 6 0 8 0 1 0 0 2 0 0 4 0 0 6 0 0 8 0 0 Days post infusion V e c t o r c o p i e s / μ g g D N A Cohort A (n=18) Cohort B (n=6) Cohort A Cohort B 0 5×10 5 1×10 6 1.5×10 6 2×10 6 2.5×10 6 V e c t o r c o p i e s / μ g g D N A p=0.0472 PR cPR PD SD (n=18) (n=6) Peak expansion (C max ) normalized to cell dose Comparable cell dose - dependent engraftment and peripheral blood kinetics of IMA203 T cells in Cohort A and C while lower tumor infiltration in combination with nivolumab Persistence over time Peak expansion (C max ) Tumor infiltration Cohort A Cohort B 1×10 0 1×10 1 1×10 2 1×10 3 1×10 4 1×10 5 I M A 2 0 3 T c e l l i n f i l t r a t i o n [ v e c t o r c o p i e s / µ g g D N A ] PR cPR SD (n=4) (n=4) p=0.0286 Cohort A Cohort B 0 2×10 5 4×10 5 6×10 5 8×10 5 V e c t o r c o p i e s / μ g g D N A p=0.6261 PR cPR PD SD (n=18) (n=6) Data cut - off Sep 30, 2023 IMA203 + Nivo

 

 

 

IMA203 T cell Activation and Differentiation Cohort A IMA203 vs. Cohort B IMA203 + Nivolumab 47 Trend towards increased terminal differentiation of IMA203 T cells and exhaustion surrogate receptor expression in combination with nivolumab Statistical Test: Mann Whitney; *TEMRA (CCR7 - CD45RA+), CD39 - CD69 - , and TIM - 3: for patients B - DL4 - 05, A - DL5 - 04, A - DL5 - 09, A - DL5 - 10, and A - DL5 - 12 data not available for week 8 TEMRA * Terminal differentiation CD39 - CD69 - Stem - like phenotype TIM - 3 Exhaustion surrogate receptor Data cut - off Sep 30, 2023 Cohort A: n=18 Cohort B: n=6 IMA203 + Nivo

 

 

 

Kinetics of PD - 1 + Frequency on IMA203 T Cells 48 Cohort A IMA203 vs. Cohort B IMA203 + Nivolumab Sustained PD - 1 expression on IMA203 T cells after initial activation observed in few patients *Patient B - DL4 - 04 did not have available samples for analysis of week 1 and month 6 Cohort A Cohort B Cohort A: n=18 Cohort B: n=6 Data cut - off Sep 30, 2023 IMA203 + Nivo

 

 

 

Patient Case B - DL4 - 04: Tumor Reduction in Multiple Large Metastatic Lesions Observed Sustained Clinical Benefit in Patient despite PD at Week 11 49 Pre - treatment Post - treatment, week 11 = bladder 1 Per treating physician; CT scans courtesy of treating physician Clinical benefit observed despite formally being a patient with early PD after unconfirmed PR according to RECIST 1.1 50 - year - old male patient with h ighly refractory malignant melanoma (unknown primary, BRAFV600E mutation) and lesions in multiple organs entering IMA203 Cohort B • 6 prior lines of systemic therapies, LDH at baseline 2.9 xULN • 5 target lesions (liver, lung, left adrenal gland, 2 lymph nodes) • 280.2 mm target lesion sum  among the patients with highest tumor burden we have treated so far • 4 non - target lesions (liver, lung, right adrenal gland, large pelvic tumor bulk) » Tumor regression in multiple lesions after IMA203 + nivolumab treatment, pelvic tumor bulk reduced from 11.5 cm to ~3.5 cm 1 » Treatment provided sustained improvement of tumor - related symptoms 1 » Patient was PD (pararenal metastases) at week 11 and switched to pembrolizumab + lenvatinib treatment 1 . As of data cut off patient is still alive ~13 months post IMA203 + nivolumab treatment 1 » Patient case study could indicate potential clinical benefit of IMA203 + checkpoint inhibitors in patients with PD - 1/PD - L1 upregulation Liver lesion ( target ) Pelvic lesion (non - target) Large pelvic lesion compressing the bladder and colon prior to treatment Data cut - off Sep 30, 2023 IMA203 + Nivo

 

 

 

Appendix – Additional Data 1. Patient Flow and PRAME Expression in Pre - Treatment Tumor Biopsies 2. Dose Escalation and Cohort A IMA203 GEN1 3. Cohort B IMA203 GEN1 + Nivolumab 4. Cohort C IMA203 GEN2 5. Manufacturing and in vivo Engraftment Data IMA203 GEN1 and IMA203CD8 GEN2

 

 

 

Tolerability Data – Cohort C IMA203CD8 GEN2 51 Adverse event ≥ Grade 3 ( System organ class , preferred term) No. % Patients with any adverse event 12 100.0 Adverse events of special interest 3 25.0 Cytokine release syndrome 1 3 25.0 Immune effector cell - associated neurotoxicity syndrome 0 0.0 Blood and lymphatic system disorders 11 91.7 Neutropenia 9 75.0 Anaemia 8 66.7 Lymphopenia 8 66.7 Thrombocytopenia 4 33.3 Leukopenia 2 16.7 Investigations 4 33.3 Aspartate aminotransferase increased 2 16.7 Neutrophil count decreased 2 16.7 Alanine aminotransferase increased 1 8.3 Blood alkaline phosphatase increased 1 8.3 Blood bilirubin increased 1 8.3 Gamma - glutamyltransferase increased 1 8.3 Metabolism and nutrition disorders 2 16.7 Hypermagnesaemia 1 8.3 Hypoalbuminaemia 1 8.3 Hypophosphataemia 1 8.3 Nervous system disorders 2 16.7 Neurotoxicity 2 1 8.3 Syncope 1 8.3 Immune system disorders 1 8.3 Haemophagocytic lymphohistiocytosis 2 1 8.3 Infections and infestations 1 8.3 Infection 1 8.3 All treatment - emergent adverse events (TEAEs) with ≥ Grade 3 regardless of relatedness to study treatment that occurred in at least 1 patient ( except for ICANS, where no event was documented; listed for completeness due to being an adverse event of special interest) are presented. Adverse events were coded using the Medical Dictionary for Regulatory Activities. Grades were determined according to National Cancer Institute Common Terminology Criteria of Adverse Events, version 5.0. Grades for CRS and ICANS were determined according to CARTOX criteria ( Neelapu et al., 2018). Patients are counted only once per adverse event and severity classification. Based on interim data extracted from open clinical database (30 - Sep - 2023) ; 1 DLT: Dose limiting toxicity in patient DL4b - 04. 2 DLTs in patient DL4b - 01 All ≥Grade 3 Adverse Events (N=12) TEAEs by maximum severity for all patients in Cohort C (N= 12 ) • Manageable tolerability • Most frequent ≥Grade 3 AEs were expected cytopenia associated with lymphodepletion • No IMA203CD8 - related Grade 5 Adverse Events • Dose escalation ongoing IMA203CD8 GEN2 Data cut - off Sep 30, 2023

 

 

 

Patients Treated in Cohort C IMA203CD8 52 Patient ID Indication No of prior treatment lines Prior treatments Total infused dose TCR - T cells 1 [x10 9 ] BOR BOR (Max % change of target lesions) Comment Reason for Progression C - DL3 - 02 Cut. Melanoma 3 Ipilimumab + Nivolumab Nivolumab Binimetinib 0.93 cPR - 74.4 Ongoing response 12.8 months post infusion C - DL4a - 01 Uveal Melanoma 4 Transarterial chemo - embolization right liver Ipilimumab + Nivolumab Pembrolizumab Tebentafusp 0.94 cPR - 45.0 Ongoing response (after initial SD) 7.8 months post infusion C - DL4a - 02 Cut. Melanoma 3 Interferon Pembrolizumab Ipilimumab + Nivolumab 1.07 cPR - 62.3 Ongoing response 5.3 months post infusion C - DL3 - 04 Synovial Sarcoma 3 Adriamycin + Ifosfamide Doxorubicin + Dacarbazine Pazopanib 1.00 cPR - 42.2 Response until 4.9 months post infusion 2 New lesions, target and non - target lesion progression 2 C - DL4b - 02 Cut. Melanoma 3 Pembrolizumab Ipilimumab + Nivolumab Nivolumab 1.78 cPR - 36.0 Ongoing response 3.4 months post infusion C - DL4a - 03 Synovial Sarcoma 2 Doxorubicin Ifosfamid 1.56 PR - 36.7 Ongoing unconfirmed response (after initial SD) 4.8 months post infusion C - DL4b - 04 Synovial Sarcoma 1 Doxorubicin + Ifosfamide + Mesna 2.05 PR - 54.5 Ongoing unconfirmed response 2.4 months post infusion C - DL3 - 01 Synovial Sarcoma 5 Doxorubicin + Ifosfamid Doxorubicin + Ifosfamid Doxorubicin Trabectedin Ifosfamid 0.89 SD - 1.1 Disease stabilization until 2.8 months post infusion New lesions, target and non - target lesion progression C - DL3 - 03 Cut. Melanoma 3 Ipilimumab + Nivolumab Dabrafenib + Trametinib Pembrolizumab + Dabrafenib + Trametinib 0.64 SD - 36.7 Disease stabilization until 2.8 months post infusion New target lesion C - DL4b - 01 Cut. Melanoma 4 CMP - 100 + Nivolumab Encorafenib + Binimetinib Ipilimumab + Nivolumab Encorafenib + Binimetinib 1.89 SD - 7.6 Disease stabilization until 2.2 months post infusion Non - target lesion progression C - DL4b - 03 Synovial Sarcoma 3 Doxorubicin + Ifosfamide Votrient Pazopanib 1.49 SD - 23.5 Ongoing disease stabilization 2.9 months post infusion C - DL4a - 04 Uterine Cancer 2 Carboplatin + Paclitaxel Pembrolizumab + Lenvatinib 1.27 PD NA Progressive disease 1.7 months post infusion New lesions, target and non - target lesion progression 1 Transduced viable CD8 T cells; 2 I nvestigator information; PD: Progressive Disease; SD: Stable Disease; PR: Partial Response; cPR : Confirmed Partial Response; BL: Baseline; BOR: Best Overall Response Data cut - off Sep 30, 2023 IMA203CD8 GEN2

 

 

 

Appendix – Additional Data 1. Patient Flow and PRAME Expression in Pre - Treatment Tumor Biopsies 2. Dose Escalation and Cohort A IMA203GEN1 3. Cohort B IMA203 GEN1 + Nivolumab 4. Cohort C IMA203 GEN2 5. Manufacturing and in vivo Engraftment Data IMA203 GEN1 and IMA203CD8 GEN2

 

 

 

Favorable TCR - T Product Characteristics and High TCR - T Levels in Patients Manufacturing Improvements Implemented in Phase 1b Enhance Key Features of the Cell Product 54 Increased peak IMA203 T cell levels in patients Robust TCR - T product features DL4 only, normalized to cell dose Data cut - off Sep 30 , 2023 *Current: T cell enrichment process using monocyte depletion (negative selection) or CD8/CD4 positive selection; prior: manuf act uring process without specific T cell enrichment Current manufacturing success rate of >95% to reach RP2D of 1 - 10x10 9 TCR - T cells for IMA203 0 1×10 6 2×10 6 3×10 6 V e c t o r c o p i e s / μ g g D N A p<0.0001 IMA203 GEN1 current (n=19) IMA203 GEN1 prior (n=26) IMA203CD8 GEN2 current (n=12) 0 20 40 60 80 100 % T C R + ( o f C D 3 + C D 8 + c e l l s ) p<0.0001 IMA203 GEN1 prior (n=26) IMA203 GEN1 current (n=22) IMA203CD8 GEN2 current (n=12) 0 20 40 60 80 100 % C D 8 + ( o f v i a b l e C D 3 + c e l l s ) p=0.0382 IMA203 GEN1 prior (n=26) IMA203 GEN1 current (n=22) IMA203CD8 GEN2 current (n=12) Manufacturing process * IMA203 GEN1 IMA203CD8 GEN2

 

 

 

Delivering s the Power of T cells to Cancer Patients © Immatics. Not for further reproduction or distribution. www.immatics.com