144 0001808968 XXXXXXXX LIVE 0001070081 PTC THERAPEUTICS, INC. 001-35969 500 WARREN CORPORATE CENTER DRIVE WARREN NJ 07059 9082227000 Klein Matthew B. Officer Director Common Fidelity Brokerage Services LLC

900 Salem Street Smithfield RI 02917

2662 170572.44 82774730 03/12/2026 NASDAQ Common 03/11/2026 Restricted Stock Vesting Issuer N 2662 03/11/2026 Compensation N Matthew Klein

500 Warren Corporate Center Drive Warren NJ 07059

Common 12/30/2025 8089 619921.55 Matthew Klein

500 Warren Corporate Center Drive Warren NJ 07059

Common 01/06/2026 5149 396203.19 Matthew Klein

500 Warren Corporate Center Drive Warren NJ 07059

Common 01/07/2026 3016 233691.14 Matthew Klein

500 Warren Corporate Center Drive Warren NJ 07059

Common 01/08/2026 2514 192193.04 Matthew Klein

500 Warren Corporate Center Drive Warren NJ 07059

Common 02/18/2026 7371 511227.50 Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution. 03/12/2026 /s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Matthew Klein