Commitments and Contingencies - Additional Information (Details)	12 Months Ended
	Dec. 31, 2021 USD ($) ft² m²	Dec. 31, 2020 USD ($)	Nov. 30, 2021 USD ($)	Mar. 31, 2019 USD ($)
Other Commitments [Line Items]
Land Subject to Ground Leases | m²	1,577
Operating leases, rent expense	$ 700,000	$ 600,000
Extension of office lease	In January 2021, the Company entered into an amendment to extend the lease, effective February 2021 with a termination date of January 2030, and increase the office and laboratory space
Gosselies, Belgium
Other Commitments [Line Items]
Operating lease, Hand serving to secure lease obligation	$ 99,000	71,000
Cambridge, Massachusetts
Other Commitments [Line Items]
Land Subject to Ground Leases | ft²	2,479
Lease expiration date	May 31, 2022
Operating lease, Letter of credit to secure lease obligation				$ 57,000
Watertown Massachusetts [Member]
Other Commitments [Line Items]
Land Subject to Ground Leases | ft²	9,068
Operating lease, Letter of credit to secure lease obligation			$ 142,000
Office and Laboratory Space | Gosselies, Belgium
Other Commitments [Line Items]
Lease Commencement Date	May 31, 2016
Lease expiration date	Dec. 31, 2021
Office and Laboratory Space | Amendment To Extend Lease [Member] | Gosselies, Belgium
Other Commitments [Line Items]
Increase Land Subject To Leases | m²	201
Office and Laboratory Space | Agreement to Extend Lease [Member] | Gosselies, Belgium
Other Commitments [Line Items]
Lease Commencement Date	Feb. 28, 2021
Increase Land Subject To Leases | m²	453
Lease expiration date	Jan. 31, 2030
Office Building [Member] | Cambridge, Massachusetts
Other Commitments [Line Items]
Lease Commencement Date	May 31, 2019
Lease expiration date	Feb. 28, 2027
Office Building [Member] | Watertown Massachusetts [Member]
Other Commitments [Line Items]
Lease Commencement Date	Nov. 30, 2021
Wu Xi Agreement
Other Commitments [Line Items]
Minimum commitments	$ 0	0
Payments for Royalties	0	0
Contract Termination
Other Commitments [Line Items]
Restructuring charges	$ 0	$ 0
Minimum
Other Commitments [Line Items]
Contractual Agreement Cancelation Notice period	30 days
Operating lease term	48 days
Maximum
Other Commitments [Line Items]
Contractual Agreement Cancelation Notice period	60 days
Operating lease term	60 months