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Stock-based compensation - Schedule of Fair Value Assumptions for Stock Options Granted (Details) - $ / shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Risk-free interest rate, minimum 0.42% 0.36%
Risk-free interest rate, maximum 1.27% 1.35%
Expected term (in years) 6 years  
Expected Volatility, minimum 92.00% 90.00%
Expected Volatility, maximum 100.00% 102.00%
Expected dividend yield 0.00% 0.00%
Minimum    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Expected term (in years)   5 years
Estimated fair value of common stock $ 20.54 $ 2.95
Maximum    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Expected term (in years)   6 years
Estimated fair value of common stock $ 46.68 $ 33.12