SCHEDULE 13G/A 0000921895-24-002787 0000918923 XXXXXXXX LIVE 2 Common Stock, $0.001 par value per share 06/30/2025 0001808865 iTeos Therapeutics, Inc. 46565G104 321 ARSENAL STREET BLDG 312, FLOOR 3, SUITE 301 WATERTOWN MA 02472 Rule 13d-1(c) BIOTECHNOLOGY VALUE FUND L P a DE 0.00 0.00 0.00 0.00 0.00 N 0 PN BVF I GP LLC a DE 0.00 0.00 0.00 0.00 0.00 N 0 OO BIOTECHNOLOGY VALUE FUND II LP a DE 0.00 0.00 0.00 0.00 0.00 N 0 PN BVF II GP LLC a DE 0.00 0.00 0.00 0.00 0.00 N 0 OO Biotechnology Value Trading Fund OS LP a E9 0.00 0.00 0.00 0.00 0.00 N 0 PN BVF Partners OS Ltd. a E9 0.00 0.00 0.00 0.00 0.00 N 0 CO BVF GP HOLDINGS LLC a DE 0.00 0.00 0.00 0.00 0.00 N 0 OO BVF PARTNERS L P/IL a DE 0.00 0.00 0.00 0.00 0.00 N 0 IA PN BVF INC/IL a DE 0.00 0.00 0.00 0.00 0.00 N 0 CO LAMPERT MARK N a X1 0.00 0.00 0.00 0.00 0.00 N 0 IN iTeos Therapeutics, Inc. 321 Arsenal St., Watertown, Massachusetts 02472 Biotechnology Value Fund, L.P. ("BVF") BVF I GP LLC ("BVF GP") Biotechnology Value Fund II, L.P. ("BVF2") BVF II GP LLC ("BVF2 GP") Biotechnology Value Trading Fund OS LP ("Trading Fund OS") BVF Partners OS Ltd. ("Partners OS") BVF GP Holdings LLC ("BVF GPH") BVF Partners L.P. ("Partners") BVF Inc. Mark N. Lampert ("Mr. Lampert") Each of the foregoing is referred to as a "Reporting Person" and collectively as the "Reporting Persons." Biotechnology Value Fund, L.P. 44 Montgomery St., 40th Floor San Francisco, California 94104 BVF I GP LLC 44 Montgomery St., 40th Floor San Francisco, California 94104 Biotechnology Value Fund II, L.P. 44 Montgomery St., 40th Floor San Francisco, California 94104 BVF II GP LLC 44 Montgomery St., 40th Floor San Francisco, California 94104 Biotechnology Value Trading Fund OS LP PO Box 309 Ugland House Grand Cayman, KY1-1104 Cayman Islands BVF Partners OS Ltd. PO Box 309 Ugland House Grand Cayman, KY1-1104 Cayman Islands BVF GP Holdings LLC 44 Montgomery St., 40th Floor San Francisco, California 94104 BVF Partners L.P. 44 Montgomery St., 40th Floor San Francisco, California 94104 BVF Inc. 44 Montgomery St., 40th Floor San Francisco, California 94104 Mark N. Lampert 44 Montgomery St., 40th Floor San Francisco, California 94104 Biotechnology Value Fund, L.P. Delaware BVF I GP LLC Delaware Biotechnology Value Fund II, L.P. Delaware BVF II GP LLC Delaware Biotechnology Value Trading Fund OS LP Cayman Islands BVF Partners OS Ltd. Cayman Islands BVF GP Holdings LLC Delaware BVF Partners L.P. Delaware BVF Inc. Delaware Mark N. Lampert United States Y As of the close of business on June 30, 2025, the Reporting Persons no longer beneficially owned any securities of the Issuer. As of the close of business on June 30, 2025, the Reporting Persons no longer beneficially owned any securities of the Issuer. See Cover Pages Items 5-9. See Cover Pages Items 5-9. See Cover Pages Items 5-9. See Cover Pages Items 5-9. N Y Y Y N See Exhibit 99.1 to the Schedule 13G filed by the Reporting Persons with the Securities and Exchange Commission on November 21, 2024. Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. BIOTECHNOLOGY VALUE FUND L P /s/ Mark N. Lampert 08/14/2025 BVF I GP LLC /s/ Mark N. Lampert 08/14/2025 BIOTECHNOLOGY VALUE FUND II LP /s/ Mark N. Lampert 08/14/2025 BVF II GP LLC /s/ Mark N. Lampert 08/14/2025 Biotechnology Value Trading Fund OS LP /s/ Mark N. Lampert 08/14/2025 BVF Partners OS Ltd. /s/ Mark N. Lampert 08/14/2025 BVF GP HOLDINGS LLC /s/ Mark N. Lampert 08/14/2025 BVF PARTNERS L P/IL /s/ Mark N. Lampert 08/14/2025 BVF INC/IL /s/ Mark N. Lampert 08/14/2025 LAMPERT MARK N /s/ Mark N. Lampert 08/14/2025