CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY - USD ($) $ in Thousands		Total	Common Stock		Common Stock Restricted stock units	Common Stock Performance stock units	Additional Paid-in Capital	[1]	Additional Paid-in Capital Restricted stock units	[1]	Accumulated Deficit	Convertible debt	Convertible debt Restricted stock units	Convertible debt Additional Paid-in Capital	[1]
Balances (in shares) at Dec. 31, 2019	[1]		20,222,000
Balances at Dec. 31, 2019		$ 57,958	$ 2	[1]			$ 457,757				$ (399,801)
Increase (Decrease) in Stockholders' Equity
Issuance of common stock under employee stock purchase plan (in shares)	[1]		46,000
Issuance of common stock under employee stock purchase plan		87					87
Issuance of common stock in conjunction with vesting of restricted stock units (in shares)	[1]				234,000
Issuance of common stock in conjunction with vesting of restricted stock units, net of employee's withholding liability									$ (336)				$ (336)
Issuance of common stock upon exercise of warrant	[1]		1,521,000
Reacquisition of equity component of 2021 and 2024 Notes												$ (19,532)		$ (19,532)
Issuance of common stock in connection with Zyla Merger (in shares)	[1]		6,370,000
Issuance of common stock in connection with the Zyla Merger		22,931	$ 1	[1]			22,930
Issuance of warrants and stock options in conjunction with the Zyla Merger		11,626					11,626
Stock-based compensation		$ 10,924					10,924
Issuance of common stock upon exercise of options (in shares)		0
Net loss and Comprehensive loss		$ (28,144)									(28,144)
Balances (in shares) at Dec. 31, 2020		28,392,149	28,393,000	[1]
Balances at Dec. 31, 2020		$ 55,514	$ 3	[1]			483,456				(427,945)
Increase (Decrease) in Stockholders' Equity
Issuance of common stock under employee stock purchase plan (in shares)	[1]		4,000
Issuance of common stock in conjunction with vesting of restricted stock units (in shares)	[1]				583,000	13,000
Issuance of common stock in conjunction with vesting of restricted stock units, net of employee's withholding liability		(418)					(418)
Issuance of common stock upon exercise of warrant	[1]		1,192,000
Stock-based compensation		$ 3,545					3,545
Issuance of common stock upon exercise of options (in shares)		72,750	73,000	[1]
Issuance of common stock upon exercise of options		$ 193					193
Issuance of common stock in connection with stock offering (in shares)	[1]		14,400,000
Issuance of common stock in connection with stock offering		44,861	$ 1	[1]			44,860
Stock split fractional shares settlement	[1]		(18,000)
Net loss and Comprehensive loss		$ (1,281)									(1,281)
Balances (in shares) at Dec. 31, 2021		44,640,444	44,640,000	[1]
Balances at Dec. 31, 2021		$ 102,414	$ 4	[1]			$ 531,636				$ (429,226)

[1] Adjusted to reflect the 1-for-4 reverse stock split effected on May 18, 2021.