X0206 3 2020-04-01 0 0001509745 LEAP THERAPEUTICS, INC. LPTX 0001808408 Sirard Cynthia C/O LEAP THERAPEUTICS, INC. 47 THORNDIKE STREET, SUITE B1-1 CAMBRIDGE MA 02141 0 1 0 0 Chief Medical Officer Employee Stock Option (Right to Buy) 4.37 2022-12-05 Common Stock 8053 D Employee Stock Option (Right to Buy) 3.97 2023-01-23 Common Stock 61 D Employee Stock Option (Right to Buy) 5.56 2024-09-08 Common Stock 2517 D Employee Stock Option (Right to Buy) 5.36 2024-09-11 Common Stock 2814 D Employee Stock Option (Right to Buy) 9.90 2027-01-19 Common Stock 69130 D Employee Stock Option (Right to Buy) 9.90 2027-01-22 Common Stock 17000 D Employee Stock Option (Right to Buy) 6.49 2027-11-28 Common Stock 75000 D Employee Stock Option (Right to Buy) 7.66 2028-04-17 Common Stock 20000 D Employee Stock Option (Right to Buy) 3.68 2028-12-04 Common Stock 20000 D Employee Stock Option (Right to Buy) 1.39 2029-06-10 Common Stock 90000 D Employee Stock Option (Right to Buy) 2.94 2030-03-01 Common Stock 150000 D The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan, 25% of which cliff vested and became exercisable on December 6, 2013 and the remainder of which vested and became exercisable in a series of 12 equal quarterly installments thereafter until the Option was fully vested. The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan, 25% of which cliff vested and became exercisable on January 24, 2014 and the remainder of which vested and became exercisable in a series of 12 equal quarterly installments thereafter until the Option was fully vested. The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan, 25% of which cliff vested and became exercisable on September 9, 2015 and the remainder of which vested and became exercisable in a series of 12 equal quarterly installments thereafter until the Option was fully vested. The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan, 25% of which cliff vested and became exercisable on September 12, 2015 and the remainder of which vested and became exercisable in a series of 12 equal quarterly installments thereafter until the Option was fully vested. The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan and fully vested and became exercisable on January 20, 2017, the date of grant. The Option was granted pursuant to Leap's Amended and Restated 2012 Equity Incentive Plan, with 25% cliff vesting and becoming exercisable on January 23, 2018 and the remainder vesting and becoming exercisable in a series of 36 equal monthly installments thereafter until the Option is fully vested. The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 48 equal monthly installments until the Option is fully vested, with the first such installment vesting on December 29, 2017. The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 48 equal monthly installments until the Option is fully vested, with the first such installment vesting on May 18, 2018. The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 48 equal monthly installments until the Option is fully vested, with the first such installment vesting on January 5, 2019. The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such installment vesting on July 11, 2019. The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such installment vesting on April 2, 2020. /s/ Douglas E. Onsi 2020-04-06