X0306 4 2022-01-03 0 0001664710 Keros Therapeutics, Inc. KROS 0001808365 Knowles Julius C/O KEROS THERAPEUTICS, INC. 99 HAYDEN AVENUE, SUITE 120, BUILDING E LEXINGTON MA 02421 1 0 0 0 Common Stock 2022-01-03 4 S 0 3678 56.82 D 366738 I See footnote Common Stock 2022-01-03 4 S 0 2406 56.82 D 249130 I See footnote Common Stock 2022-01-03 4 S 0 5094 57.83 D 361644 I See footnote Common Stock 2022-01-03 4 S 0 3318 57.83 D 245812 I See footnote Common Stock 2022-01-03 4 S 0 5236 58.96 D 356408 I See footnote Common Stock 2022-01-03 4 S 0 3412 58.96 D 242400 I See footnote Common Stock 2022-01-03 4 S 0 249 59.40 D 356159 I See footnote Common Stock 2022-01-03 4 S 0 162 59.40 D 242238 I See footnote Common Stock 2022-01-04 4 S 0 794 54.95 D 355365 I See footnote Common Stock 2022-01-04 4 S 0 524 54.95 D 241714 I See footnote Common Stock 2022-01-04 4 S 0 2124 56.10 D 353241 I See footnote Common Stock 2022-01-04 4 S 0 1383 56.10 D 240331 I See footnote Common Stock 2022-01-04 4 S 0 1707 56.95 D 351534 I See footnote Common Stock 2022-01-04 4 S 0 1113 56.95 D 239218 I See footnote Common Stock 2022-01-04 4 S 0 4151 57.99 D 347383 I See footnote Common Stock 2022-01-04 4 S 0 2704 57.99 D 236514 I See footnote Common Stock 2022-01-04 4 S 0 3367 58.86 D 344016 I See footnote Common Stock 2022-01-04 4 S 0 2195 58.86 D 234319 I See footnote Common Stock 2022-01-05 4 S 0 419 57.23 D 343597 I See footnote Common Stock 2022-01-05 4 S 0 271 57.23 D 234048 I See footnote Common Stock 2022-01-05 4 S 0 1356 58.20 D 342241 I See footnote Common Stock 2022-01-05 4 S 0 886 58.20 D 233162 I See footnote Common Stock 2022-01-05 4 S 0 667 59.00 D 341574 I See footnote Common Stock 2022-01-05 4 S 0 435 59.00 D 232727 I See footnote The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $56.30 to $57.29 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (5), (6), (7), (8), (9), (10), (11), (12), (13), (14) and (15). The securities are held by Partners Innovation Fund, LLC ("PIF I"). Partners Innovation Fund, LLC ("Partners GP I") is the ultimate general partner of PIF I. The Reporting Person, a member of the board of directors of the Issuer, is a partner of Partners GP I and as a result, may be deemed to share voting and investment power with respect to the shares held by PIF I. The securities are held by Partners Innovation Fund II, L.P. ("PIF II"). Partners Innovation Fund II, LLC ("Partners GP II") is the ultimate general partner of PIF II. The Reporting Person, a member of the board of directors of the Issuer, is a partner of Partners GP II and as a result, may be deemed to share voting and investment power with respect to the shares held by PIF II. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $57.30 to $58.24 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $58.35 to $59.33 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $59.36 to $59.45 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $54.50 to $55.48 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $55.555 to $56.53 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $56.56 to $57.53 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $57.56 to $58.55 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $58.57 to $59.36 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $56.63 to $57.56 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $57.63 to $58.62 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $58.76 to $59.25 inclusive. /s/ Keith Regnante, Attorney-in-Fact 2022-01-05