X0306 4 2021-02-11 0 0001664710 Keros Therapeutics, Inc. KROS 0001808365 Knowles Julius C/O KEROS THERAPEUTICS, INC. 99 HAYDEN AVENUE, SUITE 120, BUILDING E LEXINGTON MA 02421 1 0 0 0 Common Stock 2021-02-11 4 S 0 414 62.79 D 687251 I See footnote Common Stock 2021-02-11 4 S 0 270 62.79 D 458172 I See footnote Common Stock 2021-02-11 4 S 0 2335 63.83 D 684916 I See footnote Common Stock 2021-02-11 4 S 0 1526 63.83 D 456646 I See footnote Common Stock 2021-02-11 4 S 0 1461 64.87 D 683455 I See footnote Common Stock 2021-02-11 4 S 0 952 64.87 D 455694 I See footnote Common Stock 2021-02-11 4 S 0 2418 65.80 D 681037 I See footnote Common Stock 2021-02-11 4 S 0 1575 65.80 D 454119 I See footnote Common Stock 2021-02-11 4 S 0 316 66.65 D 680721 I See footnote Common Stock 2021-02-11 4 S 0 206 66.65 D 453913 I See footnote Common Stock 2021-02-11 4 S 0 53 67.99 D 680668 I See footnote Common Stock 2021-02-11 4 S 0 35 67.98 D 453878 I See footnote Common Stock 2021-02-12 4 S 0 1278 60.20 D 679390 I See footnote Common Stock 2021-02-12 4 S 0 833 60.20 D 453045 I See footnote Common Stock 2021-02-12 4 S 0 1397 61.03 D 677993 I See footnote Common Stock 2021-02-12 4 S 0 913 61.03 D 452132 I See footnote Common Stock 2021-02-12 4 S 0 985 62.52 D 677008 I See footnote Common Stock 2021-02-12 4 S 0 641 62.52 D 451491 I See footnote Common Stock 2021-02-12 4 S 0 814 63.14 D 676194 I See footnote Common Stock 2021-02-12 4 S 0 531 63.14 D 450960 I See footnote Common Stock 2021-02-12 4 S 0 46 63.85 D 676148 I See footnote Common Stock 2021-02-12 4 S 0 30 63.85 D 450930 I See footnote The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.28 to $63.15 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (5), (6), (7), (8) (9), (10), (11), (12), (13) and (14). The securities are held by Partners Innovation Fund, LLC ("PIF I"). Partners Innovation Fund, LLC ("Partners GP I") is the ultimate general partner of PIF I. The Reporting Person, a member of the board of directors of the Issuer, is a partner of Partners GP I and as a result, may be deemed to share voting and investment power with respect to the shares held by PIF I. The securities are held by Partners Innovation Fund II, L.P. ("PIF II"). Partners Innovation Fund II, LLC ("Partners GP II") is the ultimate general partner of PIF II. The Reporting Person, a member of the board of directors of the Issuer, is a partner of Partners GP II and as a result, may be deemed to share voting and investment power with respect to the shares held by PIF II. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $63.28 to $64.26 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.32 to $65.25 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.32 to $66.30 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $66.36 to $67.09 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $67.59 to $68.05 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $59.74 to $60.73 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.74 to $61.60 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.75 to $62.68 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.20 to $62.68 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.75 to $63.73 inclusive. /s/ Keith Regnante, Attorney-in-Fact 2021-02-16