X0306 4 2021-12-10 0 0001808158 Repare Therapeutics Inc. RPTX 0001815378 Koehler Maria C/O REPARE THERAPEUTICS INC. 7210 FREDERICK-BANTING, SUITE 100 ST-LAURENT A8 H4S 2A1 QUEBEC, CANADA 0 1 0 0 EVP, Chief Medical Officer Common Shares 2021-12-10 4 M 0 48460 2.062 A 100955 D Common Shares 2021-12-10 4 M 0 51 2.425 A 101006 D Employee Stock Option (right to buy) 2.062 2021-12-10 4 M 0 48460 0.00 D 2029-05-01 Common Shares 48460 92875 D Employee Stock Option (right to buy) 2.425 2021-12-10 4 M 0 51 0.00 D 2029-12-16 Common Shares 51 111298 D Twenty-five percent (25%) of the shares subject to the option vested on May 1, 2020, and one thirty-sixth (1/36th) of the remaining shares subject to the option vested or shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date. Twenty-five percent (25%) of the shares subject to the option vested on December 16, 2020, and one thirty-ninth (1/39th) of the remaining shares subject to the option shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date. /s/ Steve Forte, Attorney-in-Fact 2021-12-10