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Collaboration and License Agreement - Additional Information (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended
Jul. 31, 2022
Jun. 30, 2020
May 30, 2020
Mar. 31, 2023
Mar. 31, 2022
Feb. 28, 2023
Dec. 31, 2022
May 31, 2020
Bristol-Myers Squibb Company                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Non-refundable payment received       $ 50,000        
Bristol-Myers Squibb Company | Collaboration and License Agreement                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Collaboration term expiration period     42 months          
Initial nonrefundable upfront fee received   $ 50,000            
Non-refundable payment received               $ 50,000
Deferred revenue, current       27,000     $ 27,400  
Bristol-Myers Squibb Company | Collaboration and License Agreement | Product Research Activity [Member]                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Deferred revenue recognized       400        
Bristol-Myers Squibb Company | Collaboration and License Agreement | Maximum                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Milestone payments entitled to be received               301,000
Bristol-Myers Squibb Company | Collaboration and License Agreement | Maximum | Research, Development and Regulatory Milestones                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Milestone payments entitled to be received               176,000
Bristol-Myers Squibb Company | Collaboration and License Agreement | Maximum | Commercial Milestones                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Milestone payments entitled to be received               $ 125,000
Roche                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Non-refundable payment received       138,626        
Roche | Combined licenses                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Non-refundable payment received       105,327        
Roche | Collaboration and License Agreement                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Estimated period of completion of trials to get revenue 24 months              
Non-refundable payment received       134,600        
Deferred revenue recognized       5,300 $ 0      
Deferred revenue       16,700     18,000  
Deferred revenue, current       15,400     15,300  
Deferred revenue, noncurrent       1,300     $ 2,700  
Roche | Collaboration and License Agreement | Commercial Milestones                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Milestones payments       1,172,000        
Roche | Collaboration and License Agreement | Clinical trial materials                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Non-refundable payment received       5,600        
Roche | Collaboration and License Agreement | Product additional clinical development plan                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Collaboration revenue receivable           $ 4,000    
Non-refundable payment received       4,000        
Amount of additional consideration           $ 4,000    
Roche | Collaboration and License Agreement | Upfront non refundable first payment received                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Non-refundable payment received       $ 125,000