Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Revenue:
Collaboration agreements	$ 131,830	$ 7,600
Operating expenses:
Research and development, net of tax credits	119,066	90,047
General and administrative	32,560	26,213
Total operating expenses	151,626	116,260
Loss from operations	(19,796)	(108,660)
Other income (expense), net
Realized and unrealized gain (loss) on foreign exchange	308	(144)
Interest income	5,631	259
Other expense, net	(43)	(41)
Total other income, net	5,896	74
Loss before income taxes	(13,900)	(108,586)
Income tax (expense) benefit	(15,147)	1,678
Net loss	(29,047)	(106,908)
Unrealized loss on available-for-sale marketable securities	(428)	0
Total other comprehensive loss	(428)	0
Comprehensive loss	$ (29,475)	$ (106,908)
Net loss per share attributable to common shareholders--basic	$ (0.69)	$ (2.83)
Net loss per share attributable to common shareholders--diluted	$ (0.69)	$ (2.83)
Weighted-average common shares outstanding-basic	41,922,042	37,818,115
Weighted-average common shares outstanding-diluted	41,922,042	37,818,115