X0306 4 2022-06-03 1 0001808158 Repare Therapeutics Inc. RPTX 0001619298 Versant Ventures V, LLC ONE SANSOME STREET SUITE 3630 SAN FRANCISCO CA 94104 0 0 1 0 0001589098 Versant Ophthalmic Affiliates I, L.P. ONE SANSOME STREET SUITE 3630 SAN FRANCISCO CA 94104 0 0 1 0 0001589095 Versant Affiliates Fund V, L.P. ONE SANSOME STREET SUITE 3630 SAN FRANCISCO CA 94104 0 0 1 0 0001612235 Versant Venture Capital V (Canada), LP ONE SANSOME STREET SUITE 3630 SAN FRANCISCO CA 94104 0 0 1 0 0001619297 Versant Ventures V GP-GP (Canada), Inc. ONE SANSOME STREET SUITE 3630 SAN FRANCISCO CA 94104 0 0 1 0 0001589097 Versant Venture Capital V, L.P. ONE SANSOME STREET SUITE 3630 SAN FRANCISCO CA 94104 0 0 1 0 0001687880 Versant Venture Capital VI, L.P. ONE SANSOME STREET SUITE 3630 SAN FRANCISCO CA 94104 0 0 1 0 0001777654 Versant Ventures VI GP, L.P. ONE SANSOME STREET SUITE 3630 SAN FRANCISCO CA 94104 0 0 1 0 0001777652 Versant Ventures VI GP-GP, LLC ONE SANSOME STREET SUITE 3630 SAN FRANCISCO CA 94104 0 0 1 0 0001716490 Versant Ventures V (Canada), L.P. ONE SANSOME STREET SUITE 3630 SAN FRANCISCO CA 94104 0 0 1 0 Common Shares 2022-06-03 4 S 0 250000 12.2517 D 2344451 I See Footnote Common Shares 2022-06-03 4 S 0 438795 12.2517 D 1464875 I See Footnote Common Shares 2022-06-03 4 S 0 13199 12.2517 D 44065 I See Footnote Common Shares 2022-06-03 4 S 0 14611 12.2517 D 48776 I See Footnote Common Shares 2022-06-03 4 S 0 33395 12.2517 D 111484 I See Footnote Common Shares 2022-06-06 4 J 0 614315 0.00 D 850560 I See Footnote Common Shares 2022-06-06 4 J 0 132692 0.00 A 132692 D Common Shares 2022-06-06 4 J 0 18478 0.00 D 25587 I See Footnote Common Shares 2022-06-06 4 J 0 3992 0.00 A 136684 D Common Shares 2022-06-06 4 J 0 20454 0.00 D 28322 I See Footnote Common Shares 2022-06-06 4 J 0 4419 0.00 A 141103 D Common Shares 2022-06-06 4 J 0 141103 0.00 D 0 D Common Shares 2022-06-06 4 J 0 46753 0.00 D 64731 I See Footnote Common Shares 2022-06-06 4 J 0 10099 0.00 A 10099 I See Footnote Common Shares 2022-06-06 4 J 0 10099 0.00 D 0 I See Footnote Common Shares 231211 I See Footnote The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.25 to $12.50, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote (1) to this Form 4. Shares held by Versant Venture Capital VI, L.P. ("VVC VI"). Versant Ventures VI GP-GP, LLC ("VV VI GP") is the sole general partner of Versant Ventures VI GP, L.P. ("VV VI") and VV VI is the sole general partner of VVC VI. Jerel C. Davis, a member of the Issuer's board of directors, is a managing director of VV VI GP and may be deemed to share voting and dispositive power over the shares held by VVC VI. Each of VV VI GP, VV VI and Jerel C. Davis disclaims beneficial ownership of the shares held by VVC VI, except to the extent of their respective pecuniary interests therein. Jerel C. Davis is a director of the Issuer and, accordingly files separate Section 16 reports. Shares held by Versant Venture Capital V, L.P. ("VVC V"). Versant Ventures V, LLC ("VV V") is the sole general partner of VVC V. Jerel C. Davis, a member of the Issuer's board of directors, is a managing director of VV V and may be deemed to share voting and dispositive power over the shares held by VVC V. Each of VV V and Jerel C. Davis disclaims beneficial ownership of the shares held by VVC V, except to the extent of their respective pecuniary interests therein. Jerel C. Davis is a director of the Issuer and, accordingly files separate Section 16 reports. Shares held by Versant Affiliates Fund V, L.P. ("VAF V"). VV V is the sole general partner of VAF V. Jerel C. Davis, a member of the Issuer's board of directors, is a managing director of VV V and may be deemed to share voting and dispositive power over the shares held by VAF V. Each of VV V and Jerel C. Davis disclaims beneficial ownership of the shares held by VAF V, except to the extent of their respective pecuniary interests therein. Jerel C. Davis is a director of the Issuer and, accordingly files separate Section 16 reports. Shares held by Versant Ophthalmic Affiliates Fund I, L.P. ("VOAF I"). VV V is the sole general partner of VOAF I. Jerel C. Davis, a member of the Issuer's board of directors, is a managing director of VV V and may be deemed to share voting and dispositive power over the shares held by VOAF I. Each of VV V and Jerel C. Davis disclaims beneficial ownership of the shares held by VOAF I, except to the extent of their respective pecuniary interests therein. Jerel C. Davis is a director of the Issuer and, accordingly files separate Section 16 reports. Shares held by Versant Venture Capital V (Canada) LP ("VVC V (Canada)"). Versant Ventures V (Canada) GP-GP, Inc. ("VV V (Canada) GP") is the sole general partner of Versant Ventures V (Canada), L.P. ("VV V (Canada)") and VV V (Canada) is the sole general partner of VVC V (Canada). Jerel C. Davis, a member of the Issuer's board of directors, is a director of VV V (Canada) GP and may be deemed to share voting and dispositive power over the shares held by VVC V (Canada). Each of VV V (Canada), VV V (Canada) GP and Jerel C. Davis disclaims beneficial ownership of the shares held by VVC V (Canada), except to the extent of their respective pecuniary interests therein. Jerel C. Davis is a director of the Issuer and, accordingly files separate Section 16 reports. Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by VVC V to its partners. Represents a change in the form of ownership of VV V by virtue of the receipt of shares in the pro-rata in-kind distribution of common shares of the Issuer for no consideration by VVC V. Shares held by VV V. Jerel C. Davis, a member of the Issuer's board of directors, is a managing director of VV V and may be deemed to share voting and dispositive power over the shares held by VV V; however, he disclaims beneficial ownership of such securities, except to the extent of his pecuniary interest therein. Jerel C. Davis is a director of the Issuer and, accordingly files separate Section 16 reports. Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by VAF V to its partners. Represents a change in the form of ownership of VV V by virtue of the receipt of shares in the pro-rata in-kind distribution of common shares of the Issuer for no consideration by VAF V. Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by VOAF I to its partners. Represents a change in the form of ownership of VV V by virtue of the receipt of shares in the pro-rata in-kind distribution of common shares of the Issuer for no consideration by VOAF I. Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by VV V, to its members. Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by VVC V (Canada) to its partners. Represents a change in the form of ownership of VV V (Canada) by virtue of the receipt of shares in the pro-rata in-kind distribution of common shares of the Issuer for no consideration by VVC V (Canada). Shares held by VV V (Canada). VV V (Canada) GP is the sole general partner of VV V (Canada). Jerel C. Davis, a member of the Issuer's board of directors, is a director of VV V (Canada) GP and may be deemed to share voting and dispositive power over the shares held by VV V (Canada). Each of VV V (Canada) GP and Jerel C. Davis disclaims beneficial ownership of the shares held by VV V (Canada), except to the extent of their respective pecuniary interests therein. Jerel C. Davis is a director of the Issuer and, accordingly files separate Section 16 reports. Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by VV V (Canada), to its partners. Shares held by Versant Vantage I, L.P. ("VV I"). Versant Vantage I GP-GP, LLC ("VV I GP-GP") is the sole general partner of Versant Vantage I GP, L.P. ("VV I GP") and VV I GP is the sole general partner of VV I. Jerel C. Davis, a member of the Issuer's board of directors, is a managing director of VV I GP-GP and may be deemed to share voting and dispositive power over the shares held by VV I. Each of VV I GP-GP, VV I GP and Jerel C. Davis disclaims beneficial ownership of the shares held by VV I, except to the extent of their respective pecuniary interests therein. Jerel C. Davis is a director of the Issuer and, accordingly files separate Section 16 reports. 1 of 2: Since there are 13 joint filers and EDGAR will not allow for entry of more than 10 joint filers, this Form 4 is being filed in conjunction with a Form 4 for Versant Vantage I, LP, Versant Vantage I GP, L.P. and Versant Vantage I GP-GP, LLC. /s/ Robin L. Praeger, Managing Director of Versant Ventures V, LLC 2022-06-07 /s/ Robin L. Praeger, Managing Director of Versant Ventures V, LLC, general partner of Versant Ophthalmic Affiliates Fund I, L.P. 2022-06-07 /s/ Robin L. Praeger, Managing Director of Versant Ventures V, LLC, general partner of Versant Affiliates Fund V, L.P. 2022-06-07 /s/ Robin L. Praeger, Director of Versant Ventures V GP-GP (Canada), Inc., general partner of Versant Ventures V (Canada), L.P., the general partner of Versant Venture Capital V (Canada) LP 2022-06-07 /s/ Robin L. Praeger, Director of Versant Ventures V GP-GP (Canada), Inc., general partner of Versant Ventures V (Canada), L.P. 2022-06-07 /s/ Robin L. Praeger, Director of Versant Ventures V GP-GP (Canada), Inc. 2022-06-07 /s/ Robin L. Praeger, Managing Director of Versant Ventures VI GP-GP LLC, general partner of Versant Ventures VI GP, L.P., the general partner of Versant Venture Capital VI, L.P. 2022-06-07 /s/ Robin L. Praeger, Managing Director of Versant Ventures VI GP-GP LLC, general partner of Versant Ventures VI GP, L.P. 2022-06-07 /s/ Robin L. Praeger, Managing Director of Versant Ventures VI GP-GP LLC 2022-06-07 /s/ Robin L. Praeger, Managing Director of Versant Ventures V, LLC, the general partner of Versant Venture Capital V, L.P. 2022-06-07