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    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

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        <entityName>Medicenna Therapeutics Corp.</entityName>
        <issuerAddress>
            <street1>2 BLOOR STREET W</street1>
            <street2>SUITE 903</street2>
            <city>TORONTO</city>
            <stateOrCountry>A6</stateOrCountry>
            <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
            <zipCode>M4W 3E2</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>604-671-6673</issuerPhoneNumber>
        <jurisdictionOfInc>CANADA (FEDERAL LEVEL)</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>A2 Acquisition Corp.</previousName>
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        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
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            <relatedPersonName>
                <firstName>Fahar</firstName>
                <lastName>Merchant</lastName>
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            <relatedPersonAddress>
                <street1>2 Bloor Street W.</street1>
                <street2>Suite 903</street2>
                <city>Toronto</city>
                <stateOrCountry>A6</stateOrCountry>
                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M4W 3E2</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <lastName>Hyman</lastName>
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            <relatedPersonAddress>
                <street1>2 Bloor Street W.</street1>
                <street2>Suite 903</street2>
                <city>Toronto</city>
                <stateOrCountry>A6</stateOrCountry>
                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M4W 3E2</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification></relationshipClarification>
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            <relatedPersonName>
                <firstName>Nageatte</firstName>
                <lastName>Ibrahim</lastName>
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                <street2>Suite 903</street2>
                <city>Toronto</city>
                <stateOrCountry>A6</stateOrCountry>
                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M4W 3E2</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Rosemina</firstName>
                <lastName>Merchant</lastName>
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                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M4W 3E2</zipCode>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Albert</firstName>
                <middleName>G.</middleName>
                <lastName>Beraldo</lastName>
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                <street2>Suite 903</street2>
                <city>Toronto</city>
                <stateOrCountry>A6</stateOrCountry>
                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M4W 3E2</zipCode>
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                <firstName>John</firstName>
                <lastName>Geltosky</lastName>
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                <zipCode>M4W 3E2</zipCode>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Karim</firstName>
                <lastName>Lalji</lastName>
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                <city>Toronto</city>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Richard</firstName>
                <lastName>Sutin</lastName>
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                <street2>Suite 903</street2>
                <city>Toronto</city>
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                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M4W 3E2</zipCode>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Angelos</firstName>
                <lastName>Georgakis</lastName>
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                <city>Toronto</city>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2026-05-28</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Each Unit is comprised of 1 common share and 1/2 of 1 common share purchase warrant. Each Warrant entitles the holder thereof to purchase one additional Share at an exercise price of CDN$0.65 per Share for a period of 3 years following May 28, 2026.</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>2343400</totalOfferingAmount>
            <totalAmountSold>253458</totalAmountSold>
            <totalRemaining>2089942</totalRemaining>
            <clarificationOfResponse>The additional $2,089,942 may be received upon the exercise of common share purchase warrants if exercised in the U.S. U.S. dollar amounts based on the Bank of Canada average rate of exchange reported on May 28, 2026, which was CDN$1.3809 =US$1.00.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>3</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>In the ordinary course of business, the issuer may use some of the proceeds of the offering to pay salaries to certain of its executive officers and directors.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Medicenna Therapeutics Corp.</issuerName>
                <signatureName>/s/ David Hyman</signatureName>
                <nameOfSigner>David Hyman</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2026-07-06</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
